Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 6/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 2/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | LDHA | P00338 | 2/20 | 0.38 |
| ▸ | TNKS | O95271 | 4/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | PARP1 | P09874 | 2/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16625249 | 0.84 | ALDH1A1 (0.45) | TNKSALDH1A1PARP1KDM4E | |
| SCHEMBL16625331 | 0.84 | KCNA5 (0.40) | KCNA5MEN1KMT2ADRD3DRD2 | |
| SCHEMBL16625237 | 0.81 | TNKS (0.52) | MEN1KMT2ATNKSALDH1A1PARP1 | |
| SCHEMBL23302837 | 0.75 | SIGMAR1 (0.47) | KCNA5MEN1KMT2ADRD2KCNH2 | |
| SCHEMBL29882297 | 0.75 | SIGMAR1 (0.47) | KCNA5MEN1KMT2ADRD2KCNH2 | |
| SCHEMBL16625269 | 0.75 | KMT2A (0.53) | MEN1KMT2ATNKSPARP1 | |
| SCHEMBL16625165 | 0.74 | TNKS (0.56) | KCNA5KMT2ADRD3DRD2TNKS | |
| SCHEMBL23302442 | 0.72 | ACHE (0.47) | DRD2LDHAKCNH2PARP1L3MBTL1 | |
| SCHEMBL16625329 | 0.71 | TNKS (0.51) | KCNA5MEN1KMT2ADRD3DRD2 | |
| SCHEMBL16625330 | 0.70 | TNKS (0.43) | KCNA5MEN1KMT2ADRD3DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2822656-B1 | 3-ARYL-5-SUBSTITUTED-ISOQUINOLIN-1-ONE COMPOUNDS AND THEIR THERAPEUTIC USE | CANCER RES INST ROYAL (GB) | 2016-10-19 | — | — | EP | disclosed |