Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | PREP | P48147 | 2/20 | 0.44 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | BACE1 | P56817 | 2/20 | 0.42 |
| ▸ | CTSD | P07339 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | GLS | O94925 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL376485 | 1.00 | MAPT (0.55) | MAPTMEN1ALDH1A1KMT2AHPGD | |
| SCHEMBL181566 | 1.00 | MAPT (0.55) | MAPTMEN1ALDH1A1KMT2AHPGD | |
| Hydrochloric Acid SCHEMBL641221 | 0.98 | MAPT (0.53) | MAPTMEN1ALDH1A1KMT2AHPGD | |
| Hydrochloric Acid SCHEMBL31057412 | 0.98 | MAPT (0.53) | MAPTMEN1ALDH1A1KMT2AHPGD | |
| Hydrochloric Acid SCHEMBL9104390 | 0.98 | MAPT (0.53) | MAPTMEN1ALDH1A1KMT2AHPGD | |
| Oxalic Acid SCHEMBL25269098 | 0.97 | MEN1 (0.52) | MAPTMEN1ALDH1A1KMT2AHPGD | |
| Hydrochloric Acid SCHEMBL6039693 | 0.97 | MAPT (0.52) | MAPTMEN1ALDH1A1KMT2AHPGD | |
| SCHEMBL1365293 | 0.95 | HPGD (0.55) | MAPTMEN1ALDH1A1KMT2AHPGD | |
| SCHEMBL1563471 | 0.95 | HPGD (0.55) | MAPTMEN1ALDH1A1KMT2AHPGD | |
| SCHEMBL16041868 | 0.95 | HPGD (0.55) | MAPTMEN1ALDH1A1KMT2AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1488 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250101021-A1 | METHODS OF MAKING TOLEBRUTINIB | PRINCIPIA BIOPHARMA INC. (US) | 2025-03-27 | — | — | US | claimed |
| CN-119592535-A | Omega-aminotransferase ancestral enzyme mutant for efficiently catalyzing and synthesizing (R) -chiral amine compound and application thereof | 浙江科技大学 | 2025-03-11 | — | — | CN | claimed |
| CN-119574680-A | Mass spectrum detection method for N-heterocyclic ketone and/or N-heterocyclic chiral amino compound and application thereof | 北京衍微科技有限公司 | 2025-03-07 | — | — | CN | claimed |
| CN-119384411-A | Method for preparing tolmetinib | 普林斯匹亚生物制药公司 | 2025-01-28 | — | — | CN | claimed |
| CN-118995657-A | Omega-aminotransferase, mutant, carrier, engineering bacteria and application thereof | 西南大学 | 2024-11-22 | — | — | CN | claimed |
| CN-116478163-A | Process for preparing (R) -N- (1- (9H-purin-6-yl) piperidin-3-yl) acrylamides | 成都赜灵生物医药科技有限公司 | 2023-07-25 | — | — | CN | claimed |
| CN-111549011-B | Transaminase mutant from aspergillus terreus and application thereof | 卡柔恩赛生物技术湖北有限公司 | 2023-05-23 | — | — | CN | claimed |
| CN-116042560-A | Mutant of recombinant aminotransferase and application thereof | 清华大学 | 2023-05-02 | — | — | CN | claimed |
| CN-115557882-A | Preparation method of (R) -1-Boc-3-aminopiperidine | 苏州艾缇克药物化学有限公司 | 2023-01-03 | — | — | CN | claimed |
| CN-112280761-B | Recombinant transaminase, mutant of recombinant transaminase and application of mutant | 清华大学 | 2022-04-12 | — | — | CN | claimed |
| CN-113387945-A | Compound PTM-3, PTM-4, preparation method and application of preparing medicine | 陈敏 | 2021-09-14 | — | — | CN | claimed |
| CN-110724675-B | Transaminase catalyst and method for synthesizing (R) -1-tert-butoxycarbonyl-3-aminopiperidine by enzyme method | 宁波酶赛生物工程有限公司 | 2021-02-02 | — | — | CN | claimed |
| CN-112280761-A | Recombinant transaminase, mutant of recombinant transaminase and application of mutant | 清华大学 | 2021-01-29 | — | — | CN | claimed |
| CN-111549011-A | Transaminase mutant derived from aspergillus terreus and application thereof | 重庆迪维斯生物科技有限公司 | 2020-08-18 | — | — | CN | claimed |
| CN-110724675-A | Transaminase catalyst and method for synthesizing (R) -1-tert-butoxycarbonyl-3-aminopiperidine by enzyme method | 宁波酶赛生物工程有限公司 | 2020-01-24 | — | — | CN | claimed |
| US-12637453-B2 | Pyrazolopyridine inhibitors of c-Jun-n-Terminal kinases and uses thereof | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2026-05-26 | — | — | US | disclosed |
| WO-2026107406-A1 | p53 HETEROBIFUNCTIONAL CONJUGATES AND USES THEREOF | Design Therapeutics, Inc. (US) | 2026-05-21 | — | — | WO | disclosed |
| US-6476050-B2 | ANALGESICS; LIGANDS FOR VARIOUS CELLULAR RECEPTORS, INCLUDING OPIOID RECEPTORS, OTHER G-PROTEIN-COUPLED RECEPTORS AND ION CHANNELS | SEPRACOR, INC. | 2002-11-05 | — | — | US | disclosed |
| US-20010056090-A1 | 3-substituted piperidines comprising urea functionality, and methods of use thereof | SEPRACOR INC. | 2001-12-27 | — | — | US | disclosed |
| WO-2001068604-A2 | 3-SUBSTITUTED PIPERIDINES COMPRISING UREA FUNCTIONALITY, AND METHODS OF USE THEREOF | SEPRACOR, INC. (US) | 2001-09-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010056090-A1 | 3-substituted piperidines comprising urea functionality, and methods of use thereof | OPRM1, OPRL1, OPRK1 | MAPT 2668/4885MEN1 4864/4885ALDH1A1 1031/4885 |
| US-20250101021-A1 | METHODS OF MAKING TOLEBRUTINIB | ABL1, JAK2, JAK1 | MAPT 3378/4885MEN1 2792/4885ALDH1A1 2052/4885 |
| US-12637453-B2 | Pyrazolopyridine inhibitors of c-Jun-n-Terminal kinases and uses thereof | MAP3K1, MAP3K3, MAPK1 | MAPT 866/4885MEN1 3447/4885ALDH1A1 1172/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.