Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 4/20 | 0.55 |
| ▸ | CES1 | P23141 | 3/20 | 0.47 |
| ▸ | BCHE | P06276 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 6/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | THRB | P10828 | 2/20 | 0.43 |
| ▸ | TDP2 | O95551 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | CES2 | O00748 | 1/20 | 0.43 |
| ▸ | APAF1 | O14727 | 1/20 | 0.43 |
| ▸ | TERT | O14746 | 1/20 | 0.43 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30403300 | 0.82 | MAOA (0.56) | MAOACES1BCHEMAPTALDH1A1 | |
| SCHEMBL769934 | 0.80 | MAOA (0.71) | MAOACES1BCHEMAPTALDH1A1 | |
| SCHEMBL17029061 | 0.78 | MAOA (0.50) | MAOACES1BCHEMAPTALDH1A1 | |
| Fluorene SCHEMBL28830024 | 0.78 | MAOA (0.81) | MAOACES1BCHEMAPTALDH1A1 | |
| Anthrone SCHEMBL8617645 | 0.78 | MAOA (0.90) | MAOACES1BCHEMAPTALDH1A1 | |
| SCHEMBL15119561 | 0.76 | MAOA (0.48) | MAOACES1BCHEMAPTALDH1A1 | |
| Anthraquinone SCHEMBL28529223 | 0.75 | MAOA (0.85) | MAOACES1BCHEMAPTALDH1A1 | |
| Anthraquinone SCHEMBL22026730 | 0.75 | MAOA (0.95) | MAOACES1BCHEMAPTALDH1A1 | |
| SCHEMBL18156798 | 0.74 | MAOA (0.61) | MAOACES1BCHEMAPTALDH1A1 | |
| SCHEMBL5403107 | 0.74 | MAOA (0.61) | MAOACES1BCHEMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230126850-A1 | HETEROCYCLIC SPIRO COMPOUNDS | MERCK PATENT GMBH (DE) | 2023-04-27 | — | — | US | disclosed |
| US-20160308147-A1 | HETEROCYCLIC SPIRO COMPOUNDS | MERCK PATENT GMBH (DE) | 2016-10-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160308147-A1 | HETEROCYCLIC SPIRO COMPOUNDS | NES, KCNC1, HCN4 | MAOA 3085/4885CES1 4661/4885BCHE 4757/4885 |
| US-20230126850-A1 | HETEROCYCLIC SPIRO COMPOUNDS | NES, KCNC1, HCN4 | MAOA 3085/4885CES1 4661/4885BCHE 4757/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.