Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 3/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | CES1 | P23141 | 3/20 | 0.47 |
| ▸ | BCHE | P06276 | 2/20 | 0.47 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.46 |
| ▸ | USP8 | P40818 | 1/20 | 0.46 |
| ▸ | USP7 | Q93009 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18156798 | 1.00 | MAOA (0.61) | MAOAALDH1A1SMN1; SMN2MAPTNPC1 | |
| SCHEMBL29546605 | 0.96 | MAOA (0.65) | MAOAALDH1A1SMN1; SMN2MAPTNPC1 | |
| SCHEMBL23566781 | 0.96 | MAOA (0.65) | MAOAALDH1A1SMN1; SMN2MAPTNPC1 | |
| SCHEMBL20669041 | 0.89 | MAOA (0.57) | MAOAALDH1A1SMN1; SMN2MAPTNPC1 | |
| Fluorene SCHEMBL28830024 | 0.86 | MAOA (0.81) | MAOAALDH1A1SMN1; SMN2MAPTNPC1 | |
| Anthraquinone SCHEMBL28529223 | 0.84 | MAOA (0.85) | MAOAALDH1A1SMN1; SMN2MAPTNPC1 | |
| SCHEMBL5021694 | 0.82 | MAOA (0.82) | MAOAALDH1A1SMN1; SMN2MAPTNPC1 | |
| Anthrone SCHEMBL8617645 | 0.82 | MAOA (0.90) | MAOAALDH1A1SMN1; SMN2MAPTNPC1 | |
| SCHEMBL30912172 | 0.82 | SMN1; SMN2 (0.64) | MAOAALDH1A1SMN1; SMN2MAPTNPC1 | |
| SCHEMBL5016641 | 0.82 | SMN1; SMN2 (0.64) | MAOAALDH1A1SMN1; SMN2MAPTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230126850-A1 | HETEROCYCLIC SPIRO COMPOUNDS | MERCK PATENT GMBH (DE) | 2023-04-27 | — | — | US | disclosed |
| US-20160308147-A1 | HETEROCYCLIC SPIRO COMPOUNDS | MERCK PATENT GMBH (DE) | 2016-10-20 | — | — | US | disclosed |
| US-7182850-B2 | oxidation of aromatic hydrocarbons into cyclopentanone compound; oxidation of fluorene into polyfluorenone | IM&T RESEARCH, INC. (US) | 2007-02-27 | — | — | US | disclosed |
| US-7087681-B2 | Electrochemistry polymerization; blend of aromatic resin and cyclopentanone ; oxidation to polyfluorenes | IM&T RESEARCH, INC. (US) | 2006-08-08 | — | — | US | disclosed |
| US-20050045492-A1 | Method for preparing polymers containing cyclopentanone structures | IM&T RESEARCH, INC. | 2005-03-03 | — | — | US | disclosed |
| US-6835296-B2 | Electrochemical polymerization; polyfluorenone; light emitting diodes | IM&T RESEARCH, INC. | 2004-12-28 | — | — | US | disclosed |
| US-20040206633-A1 | oxidation of aromatic hydrocarbons into cyclopentanone compound; oxidation of fluorene into polyfluorenone | IM&T RESEARCH, INC. | 2004-10-21 | — | — | US | disclosed |
| US-20040210033-A1 | Electrochemistry polymerization; blend of aromatic resin and cyclopentanone ; oxidation to polyfluorenes | IM&T RESEARCH, INC. | 2004-10-21 | — | — | US | disclosed |
| US-6767446-B2 | ELECTROLYTIC POLYMERIZATION OF AROMATIC HYDROCARBONS SUCH AS FLUORENE IN THE PRESENCE OF AN ESTER; OXIDIZING RESULTING POLYMER TO PRODUCE A CYCLOPENTANONE-CONTAINING POLYMER SUCH AS POLY(9-FLUORENONE); LIGHT EMITTING DIODES | IM&T RESEARCH, INC. | 2004-07-27 | — | — | US | disclosed |
| US-20030081432-A1 | Electrolytic polymerization of aromatic hydrocarbons such as fluorene in the presence of an ester; oxidizing resulting polymer to produce a cyclopentanone-containing polymer such as poly(9-fluorenone); light emitting diodes | IM&T RESEARCH, INC. | 2003-05-01 | — | — | US | disclosed |
| US-20030066757-A1 | Method for preparing polymers containing cyclopentanone structures | IM&T RESEARCH, INC. | 2003-04-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160308147-A1 | HETEROCYCLIC SPIRO COMPOUNDS | NES, KCNC1, HCN4 | MAOA 3085/4885ALDH1A1 383/4885SMN1; SMN2 3900/4885 |
| US-20230126850-A1 | HETEROCYCLIC SPIRO COMPOUNDS | NES, KCNC1, HCN4 | MAOA 3085/4885ALDH1A1 383/4885SMN1; SMN2 3900/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.