Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 3/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.42 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.42 |
| ▸ | MMP12 | P39900 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | ACP3 | P15309 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1068632 | 0.89 | KMT2A (0.57) | SMN1; SMN2KMT2AALDH1A1GAACYP3A4 | |
| SCHEMBL11903287 | 0.89 | KMT2A (0.57) | SMN1; SMN2KMT2AALDH1A1GAACYP3A4 | |
| SCHEMBL8476179 | 0.89 | KMT2A (0.57) | SMN1; SMN2KMT2AALDH1A1GAACYP3A4 | |
| SCHEMBL5036096 | 0.85 | PTGS2 (0.58) | PTGS2SMN1; SMN2ALDH1A1GAACYP3A4 | |
| SCHEMBL5017613 | 0.84 | SRR (0.47) | PTGS2GAACYP1A2CYP2C9PKM | |
| SCHEMBL11126462 | 0.83 | ALDH1A1 (0.54) | PTGS2SMN1; SMN2ALDH1A1GAACYP3A4 | |
| SCHEMBL9999768 | 0.81 | ALDH1A1 (0.51) | PTGS2SMN1; SMN2KMT2AALDH1A1GAA | |
| SCHEMBL5009753 | 0.80 | KMT2A (0.49) | SMN1; SMN2KMT2AALDH1A1GAAL3MBTL1 | |
| SCHEMBL4280687 | 0.79 | ESR1 (0.42) | SMN1; SMN2KMT2ACYP3A4CYP1A2CYP2C9 | |
| SCHEMBL19734679 | 0.78 | AOC3 (0.42) | SMN1; SMN2KMT2AALDH1A1GAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2320886-A1 | GLUCOSYLCERAMIDE SYNTHASE INHIBITION FOR THE TREATMENT OF COLLAPSING GLOMERULOPATHY AND OTHER GLOMERULAR DISEASE | Genzyme Corporation (US) | 2011-05-18 | — | — | EP | disclosed |
| WO-2010014554-A1 | GLUCOSYLCERAMIDE SYNTHASE INHIBITION FOR THE TREATMENT OF COLLAPSING GLOMERULOPATHY AND OTHER GLOMERULAR DISEASE | GENZYME CORPORATION (US) | 2010-02-04 | — | — | WO | disclosed |