SCHEMBL1815697

SCHEMBL1815697

COC(=O)CCC(N)C(=O)N(C)C

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC1A1 P43005 2/20 0.50
TSHR P16473 4/20 0.44
KMT2A Q03164 3/20 0.44
MEN1 O00255 1/20 0.44
DPP4 P27487 1/20 0.41
DPP9 Q86TI2 1/20 0.41
LMNA P02545 2/20 0.38
KDM4E B2RXH2 1/20 0.38
L3MBTL1 Q9Y468 1/20 0.35
CA12 O43570 1/20 0.34
CA14 Q9ULX7 1/20 0.34
LTA4H P09960 1/20 0.34
HSD17B10 Q99714 2/20 0.33
GRM8 O00222 1/20 0.33
GRM6 O15303 1/20 0.33
GRIN2D O15399 1/20 0.33
GRIN3B O60391 1/20 0.33
GSR P00390 1/20 0.33
CYP1A2 P05177 1/20 0.33
GRIK1 P39086 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25533179 0.80 DPP4 (0.38) SLC1A1DPP4DPP9LTA4HGRM8
SCHEMBL12410073 0.78 TSHR (0.46) SLC1A1TSHRKMT2AMEN1LMNA
SCHEMBL16240926 0.78 DPP4 (0.62) SLC1A1TSHRKMT2AMEN1DPP4
SCHEMBL16240927 0.78 DPP4 (0.62) SLC1A1TSHRKMT2AMEN1DPP4
SCHEMBL142983 0.78 SLC1A1 (0.70) SLC1A1TSHRKMT2ALMNAKDM4E
SCHEMBL23734825 0.78 SLC1A1 (0.55) SLC1A1TSHRKMT2AMEN1LMNA
SCHEMBL4957051 0.78 ALOX15 (0.56) SLC1A1KMT2ADPP4DPP9GRM8
SCHEMBL6753794 0.78 SLC1A1 (0.55) SLC1A1TSHRKMT2AMEN1DPP4
SCHEMBL1666146 0.78 SLC1A1 (0.70) SLC1A1TSHRKMT2ALMNAKDM4E
SCHEMBL131050 0.78 SLC1A1 (0.55) SLC1A1TSHRKMT2AMEN1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9708366-B2 Treatment of fragile X syndrome using glycyl-L-2-methylprolyl-L-glutamate NEUREN PHARMACEUTICALS LTD. (NZ) 2017-07-18 US disclosed
US-9212204-B2 Treatment of rett syndrome using glycyl-L-2-methylprolyl-L-glutamic acid NEUREN PHARMACEUTICALS LIMITED (NZ) 2015-12-15 US disclosed
EP-2928300-A1 TREATMENT OF AUTISM SPECTRUM DISORDERS USING GLYCYL-L-2-METHYLPROLYL-L-GLUTAMIC ACID Neuren Pharmaceuticals Limited (NZ) 2015-10-14 EP disclosed
US-20150224164-A1 TREATMENT OF AUTISM SPECTRUM DISORDERS USING GLYCYL-L-2-METHYLPROLYL-L-GLUMATIC ACID NEUREN PHARMACEUTICALS LIMITED (NZ) 2015-08-13 US disclosed
US-20150197543-A1 Treatment of Autism Spectrum Disorders Using Glycyl-L-2-Methylprolyl-L-Glutamic Acid NEUREN PHARMACEUTICALS LIMITED (NZ) 2015-07-16 US disclosed
WO-2014085480-A1 TREATMENT OF AUTISM SPECTRUM DISORDERS USING GLYCYL-L-2-METHYLPROLYL-L-GLUTAMIC ACID NEUREN PHARMACEUTICALS LIMITED (NZ) 2014-06-05 WO disclosed
US-20140147491-A1 TREATMENT OF AUTISM SPECTRUM DISORDERS USING GLYCYL-L-2-METHYLPROLYL-L-GLUTAMIC ACID NEUREN PHARMACEUTICALS LIMITED (AU) 2014-05-29 US disclosed
US-8637567-B2 Cognitive enhancement and cognitive therapy using glycyl-L-2-methylprolyl-L-glutamic acid NEUREN PHARMACEUTICALS LTD. (NZ) 2014-01-28 US disclosed
EP-2667715-A1 TREATMENT OF AUTISM SPECTRUM DISORDERES USING GLYCYL-L-2-METHYLPROLYL-L-GLUTAMIC ACID Neuren Pharmaceuticals Limited (NZ) 2013-12-04 EP disclosed
WO-2012102832-A1 TREATMENT OF AUTISM SPECTRUM DISORDERES USING GLYCYL-L-2-METHYLPROLYL-L-GLUTAMIC ACID NEUREN PHARMACEUTICALS LIMITED (NZ) 2012-08-02 WO disclosed
US-20110112033-A1 COGNITIVE ENHANCEMENT AND COGNITIVE THERAPY USING GLYCYL-L-2-METHYLPROLYL-L-GLUTAMIC ACID NEUREN PHARMACEUTICALS LIMITED (AU) 2011-05-12 US disclosed
US-7605177-B2 Effects of glycyl-2 methyl prolyl glutamate on neurodegeneration NEUREN PHARMACEUTICALS LIMITED (NL) 2009-10-20 US disclosed
EP-1401808-B1 GPE ANALOGS AND PEPTIDOMIMETICS NEUREN PHARMACEUTICALS LTD (NZ) 2009-07-08 EP disclosed
US-20070298009-A1 Effects of glycyl-2 methyl prolyl glutamate on neurodegeneration NEUREN PHARMACEUTICALS LIMITED (NZ) 2007-12-27 US disclosed
US-20070004641-A1 Cognitive enhancement and cognitive therapy using glycyl-L-2-methylprolyl-L-glutamate NEUREN PHARMACEUTICALS LIMITED (NZ) 2007-01-04 US disclosed
US-7041314-B2 GPE analogs and peptidominetics NEUREN PHARMACEUTICALS LTD. (NZ) 2006-05-09 US disclosed
EP-1401808-A4 GPE ANALOGS AND PEPTIDOMIMETICS NEURONZ LTD (NZ) 2004-08-25 EP disclosed
EP-1401808-A2 GPE ANALOGS AND PEPTIDOMIMETICS Neuronz Limited (NZ) 2004-03-31 EP disclosed
US-20030055004-A1 GPE analogs and peptidominetics NEUREN PHARMACEUTICALS LIMITED (AU) 2003-03-20 US disclosed
WO-2002094856-A2 GPE ANALOGS AND PEPTIDOMIMETICS NEURONZ LIMITED (NZ) 2002-11-28 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070298009-A1 Effects of glycyl-2 methyl prolyl glutamate on neurodegeneration GRM2, GRM1, GLUL SLC1A1 51/4885TSHR 2852/4885KMT2A 972/4885
US-20030055004-A1 GPE analogs and peptidominetics GLUL, GCG, BAD SLC1A1 501/4885TSHR 4233/4885KMT2A 4615/4885
US-20140147491-A1 TREATMENT OF AUTISM SPECTRUM DISORDERS USING GLYCYL-L-2-METHYLPROLYL-L-GLUTAMIC ACID GRIN2D, GRM2, GRIN2A SLC1A1 278/4885TSHR 3954/4885KMT2A 800/4885
US-20150197543-A1 Treatment of Autism Spectrum Disorders Using Glycyl-L-2-Methylprolyl-L-Glutamic Acid GRIN2D, GRM2, GRIN2A SLC1A1 275/4885TSHR 3852/4885KMT2A 845/4885
US-20150224164-A1 TREATMENT OF AUTISM SPECTRUM DISORDERS USING GLYCYL-L-2-METHYLPROLYL-L-GLUMATIC ACID GRIN2D, GRM2, GRIK5 SLC1A1 456/4885TSHR 3640/4885KMT2A 696/4885
US-20110112033-A1 COGNITIVE ENHANCEMENT AND COGNITIVE THERAPY USING GLYCYL-L-2-METHYLPROLYL-L-GLUTAMIC ACID CHAT, GAP43, BDNF SLC1A1 64/4885TSHR 3226/4885KMT2A 339/4885
US-20070004641-A1 Cognitive enhancement and cognitive therapy using glycyl-L-2-methylprolyl-L-glutamate CHAT, GAP43, BCHE SLC1A1 73/4885TSHR 3101/4885KMT2A 353/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.