SCHEMBL18157918

SCHEMBL18157918

CS(=O)(=O)NC(=O)c1cccc(C(=O)NS(=O)(=O)C(F)(F)F)n1

nearest known ligand 0.49

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
PTGS1 P23219 5/20 0.49
PTGS2 P35354 5/20 0.49
SCN9A Q15858 2/20 0.44
P2RX7 Q99572 2/20 0.41
PTPN1 P18031 1/20 0.39
P4HTM Q9NXG6 2/20 0.39
POLB P06746 1/20 0.39
TERT O14746 1/20 0.38
PPARG P37231 1/20 0.37
VCP P55072 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18160600 0.92 PTGS1 (0.56) PTGS1PTGS2P2RX7POLB
SCHEMBL18157976 0.87 PTGS1 (0.61) PTGS1PTGS2P2RX7P4HTMPOLB
SCHEMBL18158125 0.85 P2RX7 (0.55) PTGS1PTGS2P2RX7POLBVCP
SCHEMBL18158128 0.82 PTGS2 (0.50) PTGS1PTGS2P2RX7VCP
SCHEMBL18157916 0.78 PTGS1 (0.51) PTGS1PTGS2SCN9AP2RX7P4HTM
SCHEMBL17853370 0.78 PTGS1 (0.40) PTGS1PTGS2P2RX7VCP
SCHEMBL10182186 0.76 PTGS1 (0.53) PTGS1PTGS2SCN9AP2RX7P4HTM
SCHEMBL248932 0.76 GRM5 (0.54) PTGS1PTGS2SCN9AP2RX7P4HTM
SCHEMBL30742464 0.76 PTGS1 (0.53) PTGS1PTGS2SCN9AP2RX7P4HTM
SCHEMBL18158126 0.76 BRD4 (0.41) PTGS1PTGS2P2RX7VCP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20180094086-A1 NEAR INFRARED ABSORBING COMPOSITION, NEAR INFRARED CUT FILTER, METHOD OF MANUFACTURING NEAR INFRARED CUT FILTER, DEVICE, METHOD OF MANUFACTURING COPPER-CONTAINING POLYMER, AND COPPER-CONTAINING POLYMER FUJIFILM CORPORATION (JP) 2018-04-05 US disclosed
US-20170227690-A1 NEAR INFRARED RAY ABSORBENT COMPOSITION, NEAR INFRARED RAY CUT FILTER, SOLID IMAGE PICKUP ELEMENT, AND CAMERA MODULE FUJIFILM CORPORATION (JP) 2017-08-10 US disclosed
US-20160304730-A1 NEAR INFRARED RADIATION-ABSORBING COMPOSITION, NEAR INFRARED RADIATION CUT-OFF FILTER AND PRODUCTION METHOD THEREFOR, AND CAMERA MODULE AND PRODUCTION METHOD THEREFOR FUJIFILM CORPORATION (JP) 2016-10-20 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170227690-A1 NEAR INFRARED RAY ABSORBENT COMPOSITION, NEAR INFRARED RAY CUT FILTER, SOLID IMAGE PICKUP ELEMENT, AND CAMERA MODULE C9, SET, CRY1 PTGS1 3758/4885PTGS2 4041/4885SCN9A 1886/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.