Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.45 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.45 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.45 |
| ▸ | FOLH1 | Q04609 | 6/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | ANPEP | P15144 | 1/20 | 0.42 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.42 |
| ▸ | CPA1 | P15085 | 1/20 | 0.41 |
| ▸ | CPA3 | P15088 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1818456 | 1.00 | CYP1A2 (0.46) | CYP1A2SLC1A3SLC1A2SLC1A1FOLH1 | |
| SCHEMBL23792325 | 0.85 | FOLH1 (0.45) | FOLH1MAPTMEN1TP53POLB | |
| SCHEMBL2777443 | 0.82 | SLC7A5 (0.59) | SLC1A3SLC1A2SLC1A1HSD17B10 | |
| SCHEMBL2777441 | 0.82 | SLC7A5 (0.59) | SLC1A3SLC1A2SLC1A1HSD17B10 | |
| Hydrochloric Acid SCHEMBL6775489 | 0.81 | SLC7A5 (0.57) | SLC1A3SLC1A2SLC1A1HSD17B10 | |
| Hydrochloric Acid SCHEMBL6775486 | 0.81 | SLC7A5 (0.57) | SLC1A3SLC1A2SLC1A1HSD17B10 | |
| SCHEMBL1817585 | 0.80 | CYP1A2 (0.50) | CYP1A2SLC1A3SLC1A2SLC1A1FOLH1 | |
| SCHEMBL6532923 | 0.80 | CYP1A2 (0.50) | CYP1A2SLC1A3SLC1A2SLC1A1FOLH1 | |
| SCHEMBL10129710 | 0.80 | ALDH1A1 (0.48) | MAPTMEN1TP53POLBMAPK1 | |
| SCHEMBL22714101 | 0.78 | GRIA2 (0.55) | CYP1A2SLC1A3SLC1A2SLC1A1FOLH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110124705-A1 | PRODRUGS OF ALPHA-2-DELTA LIGANDS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF | XENOPORT, INC. (US) | 2011-05-26 | — | — | US | claimed |
| EP-1883620-A1 | ß-AMINO ACID DERIVATIVES | Pfizer Limited (GB) | 2008-02-06 | — | — | EP | claimed |
| WO-2006120544-A1 | β-AMINO ACID DERIVATIVES | PFIZER LIMITED (GB) | 2006-11-16 | — | — | WO | claimed |
| US-20110130454-A1 | PRODRUGS OF GAMMA-AMINO ACID, ALPHA-2-DELTA LIGANDS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF | XENOPORT, INC. (US) | 2011-06-02 | — | — | US | disclosed |
| US-20110124705-A1 | PRODRUGS OF ALPHA-2-DELTA LIGANDS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF | XENOPORT, INC. (US) | 2011-05-26 | — | — | US | disclosed |
| EP-1883620-A1 | ß-AMINO ACID DERIVATIVES | Pfizer Limited (GB) | 2008-02-06 | — | — | EP | disclosed |
| WO-2006120544-A1 | β-AMINO ACID DERIVATIVES | PFIZER LIMITED (GB) | 2006-11-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110130454-A1 | PRODRUGS OF GAMMA-AMINO ACID, ALPHA-2-DELTA LIGANDS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF | CHRND, CHRNE, OPRD1 | CYP1A2 395/4885SLC1A3 491/4885SLC1A2 124/4885 |
| US-20110124705-A1 | PRODRUGS OF ALPHA-2-DELTA LIGANDS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF | CHRND, CHRNE, CHRNG | CYP1A2 174/4885SLC1A3 3365/4885SLC1A2 1873/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.