Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 15/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.38 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2029589 | 0.81 | KIF11 (0.51) | KIF11DNMT1 | |
| SCHEMBL2032145 | 0.81 | KIF11 (0.51) | KIF11DNMT1 | |
| SCHEMBL20271003 | 0.76 | KIF11 (0.46) | KIF11MAPTKMT2ADNMT1 | |
| SCHEMBL20271001 | 0.76 | KIF11 (0.46) | KIF11MAPTKMT2ADNMT1 | |
| SCHEMBL431461 | 0.76 | KIF11 (0.46) | KIF11MAPTKMT2ADNMT1 | |
| SCHEMBL4365780 | 0.75 | CYP1A2 (0.47) | KIF11CYP1A2CYP2D6MAPTKMT2A | |
| SCHEMBL430340 | 0.75 | CYP1A2 (0.47) | KIF11CYP1A2CYP2D6MAPTKMT2A | |
| SCHEMBL28485167 | 0.73 | MAPT (0.45) | KIF11CYP1A2CYP2D6MAPTKMT2A | |
| SCHEMBL17582896 | 0.73 | CYP2D6 (0.46) | KIF11CYP1A2CYP2D6MAPTKMT2A | |
| SCHEMBL20184852 | 0.73 | CYP2D6 (0.46) | KIF11CYP1A2CYP2D6MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160303251-A1 | CONJUGATES OF GARFTASE INHIBITORS | ENDOCYTE, INC. | 2016-10-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160303251-A1 | CONJUGATES OF GARFTASE INHIBITORS | DHFR, FOLR1, MTHFD1 | KIF11 2722/4885CYP1A2 2386/4885CYP2D6 1293/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.