Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | DPP4 | P27487 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | ESR1 | P03372 | 6/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 6/20 | 0.36 |
| ▸ | MAOB | P27338 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL18150270 | 0.98 | THRB (0.39) | ALDH1A1MAPTKDM4ELMNAGAA | |
| Hydrochloric Acid SCHEMBL18154539 | 0.86 | THRB (0.38) | ALDH1A1MAPTKDM4ELMNAGAA | |
| SCHEMBL18154544 | 0.83 | THRB (0.40) | ALDH1A1MAPTKDM4ELMNAGAA | |
| SCHEMBL7232014 | 0.83 | THRB (0.40) | ALDH1A1MAPTKDM4ELMNAGAA | |
| SCHEMBL7224874 | 0.83 | THRB (0.43) | ALDH1A1MAPTKDM4ELMNAGAA | |
| SCHEMBL18150269 | 0.81 | THRB (0.41) | ALDH1A1MAPTKDM4ELMNAGAA | |
| SCHEMBL7225366 | 0.81 | THRB (0.38) | ALDH1A1MAPTKDM4ELMNAGAA | |
| SCHEMBL20807322 | 0.80 | MTNR1A (0.39) | ALDH1A1MAPTKDM4ELMNAGAA | |
| SCHEMBL7223146 | 0.80 | AKR1B1 (0.43) | ALDH1A1KDM4ELMNAGAATHRB | |
| SCHEMBL7232217 | 0.75 | ESR1 (0.44) | ALDH1A1KDM4EGAAKMT2AESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3283481-B1 | CHROMENE DERIVATIVES AS PHOSHOINOSITIDE 3-KINASES INHIBITORS | CHIESI FARM SPA (IT) | 2019-03-13 | — | — | EP | disclosed |
| US-9968604-B2 | Chromene derivatives as phoshoinositide 3-kinases inhibitors | CHIESI FARMACEUTICI S.P.A. (IT) | 2018-05-15 | — | — | US | disclosed |
| US-9968604-B2 | Chromene derivatives as phoshoinositide 3-kinases inhibitors | CHIESI FARMACEUTICI S.P.A. (IT) | 2018-05-15 | — | — | US | disclosed |
| WO-2016166239-A1 | CHROMENE DERIVATIVES AS PHOSHOINOSITIDE 3-KINASES INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2016-10-20 | — | — | WO | disclosed |
| US-20160303123-A1 | CHROMENE DERIVATIVES AS PHOSHOINOSITIDE 3-KINASES INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2016-10-20 | — | — | US | disclosed |
| US-20160303123-A1 | CHROMENE DERIVATIVES AS PHOSHOINOSITIDE 3-KINASES INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2016-10-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160303123-A1 | CHROMENE DERIVATIVES AS PHOSHOINOSITIDE 3-KINASES INHIBITORS | PIKFYVE, PI4KA, PIP4K2B | ALDH1A1 4568/4885MAPT 4705/4885KDM4E 3065/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.