Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | ESR1 | P03372 | 6/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 6/20 | 0.36 |
| ▸ | MAOB | P27338 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.33 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7232014 | 0.83 | THRB (0.40) | THRBKMT2AMAPTKDM4EALDH1A1 | |
| SCHEMBL7224874 | 0.83 | THRB (0.43) | THRBKMT2AMAPTKDM4EALDH1A1 | |
| SCHEMBL18161998 | 0.83 | ALDH1A1 (0.40) | THRBKMT2AMAPTKDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL18150270 | 0.82 | THRB (0.39) | THRBKMT2AMAPTKDM4EALDH1A1 | |
| SCHEMBL7225366 | 0.81 | THRB (0.38) | THRBKMT2AMAPTKDM4EALDH1A1 | |
| SCHEMBL18150269 | 0.81 | THRB (0.41) | THRBKMT2AMAPTKDM4EALDH1A1 | |
| SCHEMBL7223146 | 0.80 | AKR1B1 (0.43) | THRBKMT2AKDM4EALDH1A1GAA | |
| SCHEMBL20807322 | 0.80 | MTNR1A (0.39) | THRBKMT2AMAPTKDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL18154539 | 0.80 | THRB (0.38) | THRBKMT2AMAPTKDM4EALDH1A1 | |
| SCHEMBL7232217 | 0.75 | ESR1 (0.44) | KMT2AKDM4EALDH1A1GAAESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3283481-A1 | CHROMENE DERIVATIVES AS PHOSHOINOSITIDE 3-KINASES INHIBITORS | Chiesi Farmaceutici S.p.A. (IT) | 2018-02-21 | — | — | EP | disclosed |
| WO-2016166239-A1 | CHROMENE DERIVATIVES AS PHOSHOINOSITIDE 3-KINASES INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2016-10-20 | — | — | WO | disclosed |