Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 2/20 | 0.40 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | PRKCG | P05129 | 1/20 | 0.40 |
| ▸ | CDK1 | P06493 | 1/20 | 0.40 |
| ▸ | PRKACA | P17612 | 1/20 | 0.40 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | AKT1 | P31749 | 1/20 | 0.40 |
| ▸ | AKT2 | P31751 | 1/20 | 0.40 |
| ▸ | FLT4 | P35916 | 1/20 | 0.40 |
| ▸ | GSK3A | P49840 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.40 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.40 |
| ▸ | PRKX | P51817 | 1/20 | 0.40 |
| ▸ | NEK4 | P51957 | 1/20 | 0.40 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.40 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18166440 | 0.92 | MARS1 (0.40) | F2KMT2AALDH1A1MEN1MAPT | |
| SCHEMBL18166266 | 0.92 | KMT2A (0.43) | ROCK1RPS6KA5MAP4K4PRKCGCDK1 | |
| SCHEMBL18166286 | 0.91 | ROCK1 (0.40) | ROCK1RPS6KA5MAP4K4PRKCGCDK1 | |
| SCHEMBL18166354 | 0.88 | KMT2A (0.38) | ROCK1RPS6KA5MAP4K4PRKCGCDK1 | |
| SCHEMBL10243148 | 0.87 | F2 (0.45) | ROCK1RPS6KA5MAP4K4PRKCGCDK1 | |
| SCHEMBL18036398 | 0.85 | HPGD (0.39) | F2KMT2ATDP1MEN1MAPT | |
| SCHEMBL18166408 | 0.83 | MARS1 (0.46) | ROCK1F2KMT2AMEN1MAPT | |
| SCHEMBL18166327 | 0.83 | ROCK1 (0.39) | ROCK1RPS6KA5MAP4K4PRKCGCDK1 | |
| SCHEMBL18166303 | 0.82 | ROCK1 (0.39) | ROCK1RPS6KA5MAP4K4PRKCGCDK1 | |
| SCHEMBL18166425 | 0.82 | KMT2A (0.44) | ROCK1RPS6KA5MAP4K4PRKCGCDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2038264-B1 | TETRAZOLE-SUBSTITUTED ARYLAMIDES | HOFFMANN LA ROCHE (CH) | 2016-10-26 | — | — | EP | claimed |