Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 4/20 | 0.39 |
| ▸ | PRKACA | P17612 | 3/20 | 0.39 |
| ▸ | GSK3A | P49840 | 3/20 | 0.39 |
| ▸ | GSK3B | P49841 | 3/20 | 0.39 |
| ▸ | PRKX | P51817 | 3/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.39 |
| ▸ | PRKCG | P05129 | 2/20 | 0.39 |
| ▸ | CDK1 | P06493 | 2/20 | 0.39 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.39 |
| ▸ | CDK2 | P24941 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | AKT1 | P31749 | 2/20 | 0.39 |
| ▸ | IRAK1 | P51617 | 2/20 | 0.39 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.39 |
| ▸ | NEK4 | P51957 | 2/20 | 0.39 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.39 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.39 |
| ▸ | PRKG2 | Q13237 | 2/20 | 0.39 |
| ▸ | PRKG1 | Q13976 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18166303 | 0.93 | ROCK1 (0.39) | ROCK1PRKACAGSK3AGSK3BPRKX | |
| SCHEMBL18166307 | 0.92 | MARS1 (0.37) | ROCK1ROCK2CYP3A4CYP2C9ACKR3 | |
| SCHEMBL18166266 | 0.91 | KMT2A (0.43) | ROCK1PRKACAGSK3AGSK3BPRKX | |
| SCHEMBL10243040 | 0.87 | ROCK1 (0.43) | ROCK1PRKACAGSK3AGSK3BPRKX | |
| SCHEMBL18166408 | 0.85 | MARS1 (0.46) | ROCK1ROCK2DGAT2KCNA5LMNA | |
| SCHEMBL18166449 | 0.85 | ACKR3 (0.38) | MAPK1ACKR3KCNH2 | |
| SCHEMBL18166321 | 0.84 | KMT2A (0.44) | ROCK1PRKACAGSK3AGSK3BPRKX | |
| SCHEMBL18166286 | 0.83 | ROCK1 (0.40) | ROCK1PRKACAGSK3AGSK3BPRKX | |
| SCHEMBL18166314 | 0.83 | ROCK1 (0.40) | ROCK1PRKACAGSK3AGSK3BPRKX | |
| SCHEMBL18166354 | 0.83 | KMT2A (0.38) | ROCK1PRKACAGSK3AGSK3BPRKX |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2038264-B1 | TETRAZOLE-SUBSTITUTED ARYLAMIDES | HOFFMANN LA ROCHE (CH) | 2016-10-26 | — | — | EP | claimed |