Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.33 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.31 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.31 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.31 |
| ▸ | PRKACA | P17612 | 1/20 | 0.31 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.31 |
| ▸ | CDK2 | P24941 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | AKT1 | P31749 | 1/20 | 0.31 |
| ▸ | AKT2 | P31751 | 1/20 | 0.31 |
| ▸ | GSK3A | P49840 | 1/20 | 0.31 |
| ▸ | GSK3B | P49841 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18166375 | 0.91 | P2RX3 (0.35) | ALDH1A1MAPTP2RX3P2RX2ROCK1 | |
| SCHEMBL18166394 | 0.90 | ROCK1 (0.38) | LMNAP2RX3P2RX2KMT2ARPS6KA5 | |
| SCHEMBL18166271 | 0.87 | P2RX3 (0.48) | P2RX3P2RX2 | |
| SCHEMBL10244883 | 0.87 | P2RX3 (0.46) | LMNAALDH1A1MAPTCNR1P2RX3 | |
| SCHEMBL18166288 | 0.86 | P2RX3 (0.37) | ALDH1A1CNR1P2RX3P2RX2MAPK1 | |
| SCHEMBL18036329 | 0.86 | P2RX3 (0.33) | LMNAMAPTP2RX3P2RX2KMT2A | |
| SCHEMBL18036352 | 0.86 | P2RX3 (0.33) | LMNAMAPTP2RX3P2RX2KMT2A | |
| SCHEMBL18036373 | 0.84 | DGAT2 (0.32) | LMNAMAPTKMT2AMEN1TP53 | |
| SCHEMBL18166460 | 0.82 | AKR1C3 (0.38) | ALDH1A1P2RX3P2RX2RPS6KA5PRKACA | |
| SCHEMBL18166279 | 0.79 | P2RX3 (0.42) | LMNAMAPTP2RX3P2RX2ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2038264-B1 | TETRAZOLE-SUBSTITUTED ARYLAMIDES | HOFFMANN LA ROCHE (CH) | 2016-10-26 | — | — | EP | claimed |