Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX3 | P56373 | 1/20 | 0.35 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.35 |
| ▸ | MAP3K5 | Q99683 | 5/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.33 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18166340 | 0.91 | LMNA (0.36) | P2RX3P2RX2MAP3K5P2RX7ROCK1 | |
| SCHEMBL18166460 | 0.91 | AKR1C3 (0.38) | P2RX3P2RX2MAP3K5ROCK2ROCK1 | |
| SCHEMBL18166271 | 0.88 | P2RX3 (0.48) | P2RX3P2RX2 | |
| SCHEMBL10244704 | 0.87 | P2RX3 (0.48) | P2RX3P2RX2MAP3K5P2RX7ROCK2 | |
| SCHEMBL18166288 | 0.86 | P2RX3 (0.37) | P2RX3P2RX2MAP3K5TSHRPOLB | |
| SCHEMBL18036329 | 0.84 | P2RX3 (0.33) | P2RX3P2RX2MAP3K5MAPT | |
| SCHEMBL18036352 | 0.84 | P2RX3 (0.33) | P2RX3P2RX2MAP3K5MAPT | |
| SCHEMBL18036373 | 0.82 | DGAT2 (0.32) | KDM4EMAPT | |
| SCHEMBL18166394 | 0.82 | ROCK1 (0.38) | P2RX3P2RX2MAP3K5ROCK2ROCK1 | |
| SCHEMBL18166284 | 0.81 | MAP3K5 (0.35) | P2RX3P2RX2MAP3K5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2038264-B1 | TETRAZOLE-SUBSTITUTED ARYLAMIDES | HOFFMANN LA ROCHE (CH) | 2016-10-26 | — | — | EP | claimed |