Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX3 | P56373 | 1/20 | 0.50 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.50 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | STAT3 | P40763 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | MMP13 | P45452 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | PPID | Q08752 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18166332 | 0.90 | EPHX1 (0.52) | P2RX3P2RX2EPHX1CYP3A4MMP13 | |
| SCHEMBL18166272 | 0.89 | P2RX3 (0.47) | P2RX3P2RX2EPHX1SMN1; SMN2CYP3A4 | |
| SCHEMBL18166351 | 0.88 | P2RX3 (0.46) | P2RX3P2RX2EPHX1SMN1; SMN2LMNA | |
| SCHEMBL18166329 | 0.87 | P2RX3 (0.46) | P2RX3P2RX2EPHX1SMN1; SMN2LMNA | |
| SCHEMBL18166435 | 0.87 | P2RX3 (0.48) | P2RX3P2RX2EPHX1SMN1; SMN2LMNA | |
| SCHEMBL18166398 | 0.86 | P2RX3 (0.57) | P2RX3P2RX2EPHX1SMN1; SMN2LMNA | |
| SCHEMBL18166323 | 0.86 | P2RX3 (0.47) | P2RX3P2RX2EPHX1SMN1; SMN2CYP3A4 | |
| SCHEMBL10244646 | 0.85 | P2RX3 (0.62) | P2RX3P2RX2SMN1; SMN2MMP2CYP3A4 | |
| SCHEMBL18166414 | 0.85 | P2RX3 (0.48) | P2RX3P2RX2SMN1; SMN2L3MBTL1LMNA | |
| SCHEMBL18166378 | 0.85 | P2RX3 (0.48) | P2RX3P2RX2SMN1; SMN2L3MBTL1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2038264-B1 | TETRAZOLE-SUBSTITUTED ARYLAMIDES | HOFFMANN LA ROCHE (CH) | 2016-10-26 | — | — | EP | claimed |