Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | UBE2N | P61088 | 2/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 5/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.48 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.47 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.47 |
| ▸ | ADORA2B | P29275 | 4/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4533674 | 0.90 | CYP1A2 (0.50) | LMNASMN1; SMN2HTTUBE2NCYP1A2 | |
| SCHEMBL18166745 | 0.88 | LMNA (0.55) | LMNASMN1; SMN2HTTUBE2NCYP1A2 | |
| SCHEMBL10151088 | 0.80 | ALDH1A1 (0.65) | LMNASMN1; SMN2CYP1A2CYP3A4RXFP1 | |
| SCHEMBL3798953 | 0.79 | RXFP1 (0.70) | CYP1A2RXFP1POLBKMT2ATP53 | |
| SCHEMBL1064795 | 0.75 | CYP1A2 (0.73) | LMNASMN1; SMN2HTTUBE2NCYP1A2 | |
| SCHEMBL10114081 | 0.73 | RXFP1 (0.70) | CYP1A2RXFP1POLBKMT2ATP53 | |
| SCHEMBL12584444 | 0.73 | CYP1A2 (0.71) | LMNASMN1; SMN2HTTUBE2NCYP1A2 | |
| SCHEMBL18166655 | 0.73 | ADORA2B (0.52) | LMNASMN1; SMN2RXFP1POLBKMT2A | |
| SCHEMBL15394708 | 0.73 | RXFP1 (0.67) | CYP1A2RXFP1POLBKMT2ATP53 | |
| SCHEMBL20161634 | 0.72 | LMNA (0.68) | LMNASMN1; SMN2HTTUBE2NCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3663295-A1 | 2,6-DIOXO,-2,3-DIHYDRO-1H-PURINE COMPOUNDS USEFUL FOR TREATING DISORDERS RELATED TO THE ACTIVITY OF THE TRPA1 CHANNEL | ELI LILLY AND CO. (US) | 2020-06-10 | — | — | EP | disclosed |
| EP-3184527-A1 | 2,6-DIOXO,-2,3-DIHYDRO-1H-PURINE COMPOUNDS USEFUL FOR TREATING DISORDERS RELATED TO THE ACTIVITY OF THE TRPA1 CHANNEL | Hydra Biosciences, Inc. (US) | 2017-06-28 | — | — | EP | disclosed |
| EP-2170309-B1 | 2,6-DIOXO,-2,3-DIHYDRO-1H-PURINE COMPOUNDS USEFUL FOR TREATING DISORDERS RELATED TO THE ACTIVITY OF THE TRPA1 CHANNEL | HYDRA BIOSCIENCES INC (US) | 2016-10-26 | — | — | EP | disclosed |