Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.67 |
| ▸ | RXFP1 | Q9HBX9 | 4/20 | 0.65 |
| ▸ | PORCN | Q9H237 | 3/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.61 |
| ▸ | MAPT | P10636 | 2/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.61 |
| ▸ | HPGD | P15428 | 1/20 | 0.61 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.61 |
| ▸ | HTT | P42858 | 1/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | ATM | Q13315 | 1/20 | 0.54 |
| ▸ | THRB | P10828 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18166637 | 0.91 | HSD17B10 (0.67) | HSD17B10RXFP1PORCNALDH1A1MAPT | |
| SCHEMBL18166765 | 0.90 | HSD17B10 (0.78) | HSD17B10RXFP1PORCNALDH1A1CYP2C9 | |
| SCHEMBL18166657 | 0.83 | MAPT (0.82) | RXFP1PORCNMAPTCYP1A2ALOX15 | |
| SCHEMBL3826453 | 0.83 | TRPA1 (0.77) | RXFP1PORCNCYP1A2ALOX15TP53 | |
| SCHEMBL17626504 | 0.82 | PORCN (0.63) | RXFP1PORCNMAPTCYP1A2ALOX15 | |
| SCHEMBL17200781 | 0.82 | RXFP1 (0.68) | HSD17B10RXFP1PORCNALDH1A1MAPT | |
| SCHEMBL17628692 | 0.81 | PORCN (0.82) | RXFP1PORCNALDH1A1MAPTCYP1A2 | |
| SCHEMBL15727746 | 0.81 | HSD17B10 (0.75) | HSD17B10RXFP1ALDH1A1CYP2C9HPGD | |
| SCHEMBL10113976 | 0.79 | LMNA (0.70) | RXFP1CYP1A2ALOX15TP53TSHR | |
| SCHEMBL10113960 | 0.79 | HSD17B10 (0.72) | HSD17B10RXFP1ALDH1A1CYP2C9HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3663295-A1 | 2,6-DIOXO,-2,3-DIHYDRO-1H-PURINE COMPOUNDS USEFUL FOR TREATING DISORDERS RELATED TO THE ACTIVITY OF THE TRPA1 CHANNEL | ELI LILLY AND CO. (US) | 2020-06-10 | — | — | EP | disclosed |
| EP-3184527-A1 | 2,6-DIOXO,-2,3-DIHYDRO-1H-PURINE COMPOUNDS USEFUL FOR TREATING DISORDERS RELATED TO THE ACTIVITY OF THE TRPA1 CHANNEL | Hydra Biosciences, Inc. (US) | 2017-06-28 | — | — | EP | disclosed |
| EP-2170309-B1 | 2,6-DIOXO,-2,3-DIHYDRO-1H-PURINE COMPOUNDS USEFUL FOR TREATING DISORDERS RELATED TO THE ACTIVITY OF THE TRPA1 CHANNEL | HYDRA BIOSCIENCES INC (US) | 2016-10-26 | — | — | EP | disclosed |
| CN-101801362-B | Methods and compositions for treating disorders | HYDRA BIOSCIENCES INC | 2014-01-22 | — | — | CN | disclosed |
| CN-101801362-A | methods and compositions for treating disorders | HYDRA BIOSCIENCES INC | 2010-08-11 | — | — | CN | disclosed |