Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Tryptophan. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE known ✓ | P12821 | 1/20 | 0.39 |
| ▸ | CTSC | P53634 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MPO | P05164 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | MMP1 | P03956 | 2/20 | 0.41 |
| ▸ | KISS1R | Q969F8 | 2/20 | 0.40 |
| ▸ | ERAP2 | Q6P179 | 2/20 | 0.39 |
| ▸ | ERAP1 | Q9NZ08 | 2/20 | 0.39 |
| ▸ | LNPEP | Q9UIQ6 | 2/20 | 0.39 |
| ▸ | CCKBR | P32239 | 1/20 | 0.39 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dl-Tryptophan SCHEMBL28221613 | 0.90 | CTSC (0.54) | CTSCMEN1KMT2AKDM4ELMNA | |
| Tryptophan SCHEMBL18171551 | 0.90 | CTSC (0.54) | CTSCMEN1KMT2AKDM4ELMNA | |
| Tryptophan SCHEMBL6246810 | 0.84 | CTSC (0.54) | CTSCMEN1KMT2AKDM4ELMNA | |
| Tryptophan SCHEMBL6244660 | 0.83 | CTSC (0.52) | CTSCMEN1KMT2AKDM4ELMNA | |
| Tryptophan SCHEMBL6247563 | 0.83 | CTSC (0.52) | CTSCMEN1KMT2AKDM4ELMNA | |
| Tryptophan SCHEMBL23698367 | 0.82 | CTSC (0.51) | CTSCMEN1KMT2AKDM4ELMNA | |
| Dl-Tryptophan SCHEMBL28798150 | 0.82 | KDM4E (0.68) | CTSCMEN1KMT2AKDM4ELMNA | |
| Dl-Tryptophan SCHEMBL1533586 | 0.82 | KDM4E (0.68) | CTSCMEN1KMT2AKDM4ELMNA | |
| Dl-Tryptophan SCHEMBL20164946 | 0.82 | KDM4E (0.68) | CTSCMEN1KMT2AKDM4ELMNA | |
| Dl-Tryptophan SCHEMBL28512622 | 0.82 | KDM4E (0.68) | CTSCMEN1KMT2AKDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016169239-A1 | 5 PEPTIDE RELATED WITH INTEGRIN RECEPTOR ΑVΒ3 | 中国药科大学 | 2016-10-27 | — | — | WO | disclosed |