Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Tryptophan. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE known ✓ | P12821 | 1/20 | 0.41 |
| ▸ | CTSC | P53634 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | MPO | P05164 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | BLM | P54132 | 1/20 | 0.50 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.50 |
| ▸ | FNTA | P49354 | 4/20 | 0.41 |
| ▸ | FNTB | P49356 | 4/20 | 0.41 |
| ▸ | PGGT1B | P53609 | 4/20 | 0.41 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.40 |
| ▸ | MMP1 | P03956 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tryptophan SCHEMBL23698358 | 0.91 | CTSC (0.43) | CTSCMEN1KMT2AKDM4EMAPT | |
| Dl-Tryptophan SCHEMBL22495172 | 0.90 | KDM4E (0.61) | MEN1KMT2AKDM4EMAPTLMNA | |
| Tryptophan SCHEMBL6274044 | 0.90 | KDM4E (0.61) | MEN1KMT2AKDM4EMAPTLMNA | |
| Dl-Tryptophan SCHEMBL28221613 | 0.89 | CTSC (0.54) | CTSCMEN1KMT2AKDM4EMAPT | |
| Tryptophan SCHEMBL18171551 | 0.89 | CTSC (0.54) | CTSCMEN1KMT2AKDM4EMAPT | |
| Tryptophan SCHEMBL6246810 | 0.88 | CTSC (0.54) | CTSCMEN1KMT2AKDM4EMAPT | |
| Tryptophan SCHEMBL6247563 | 0.87 | CTSC (0.52) | CTSCMEN1KMT2AKDM4EMAPT | |
| Tryptophan SCHEMBL6244660 | 0.87 | CTSC (0.52) | CTSCMEN1KMT2AKDM4EMAPT | |
| Dl-Tryptophan SCHEMBL1533586 | 0.86 | KDM4E (0.68) | CTSCMEN1KMT2AKDM4EMAPT | |
| Dl-Tryptophan SCHEMBL20164946 | 0.86 | KDM4E (0.68) | CTSCMEN1KMT2AKDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210284971-A1 | CULTURE ADDITIVE, CULTURE MEDIUM AND CULTURE METHOD FOR ANIMAL CELLS | AJINOMOTO CO., INC. (JP) | 2021-09-16 | — | — | US | disclosed |
| EP-3858980-A1 | CULTURE ADDITIVE, CULTURE MEDIUM AND CULTURE METHOD FOR ANIMAL CELLS | AJINOMOTO CO., INC. (JP) | 2021-08-04 | — | — | EP | disclosed |