Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Tryptophan. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSC | P53634 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | BLM | P54132 | 2/20 | 0.53 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.53 |
| ▸ | MPO | P05164 | 1/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.53 |
| ▸ | MMP1 | P03956 | 2/20 | 0.43 |
| ▸ | APAF1 | O14727 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | CCKBR | P32239 | 1/20 | 0.41 |
| ▸ | KISS1R | Q969F8 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dl-Tryptophan SCHEMBL28221613 | 1.00 | CTSC (0.54) | CTSCKMT2AKDM4EMAPTMEN1 | |
| Tryptophan SCHEMBL6246810 | 0.93 | CTSC (0.54) | CTSCKMT2AKDM4EMAPTMEN1 | |
| Tryptophan SCHEMBL6247563 | 0.91 | CTSC (0.52) | CTSCKMT2AKDM4EMAPTMEN1 | |
| Tryptophan SCHEMBL6244660 | 0.91 | CTSC (0.52) | CTSCKMT2AKDM4EMAPTMEN1 | |
| Tryptophan SCHEMBL8898168 | 0.91 | KDM4E (0.58) | KMT2AKDM4EMAPTMEN1LMNA | |
| Dl-Tryptophan SCHEMBL8898162 | 0.91 | KDM4E (0.58) | KMT2AKDM4EMAPTMEN1LMNA | |
| Tryptophan SCHEMBL9218670 | 0.91 | KDM4E (0.58) | KMT2AKDM4EMAPTMEN1LMNA | |
| Dl-Tryptophan SCHEMBL9218663 | 0.91 | KDM4E (0.58) | KMT2AKDM4EMAPTMEN1LMNA | |
| Tryptophan SCHEMBL2525328 | 0.90 | KDM4E (0.57) | KMT2AKDM4EMAPTMEN1LMNA | |
| Tryptophan SCHEMBL18171550 | 0.90 | CTSC (0.47) | CTSCKMT2AKDM4EMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180141974-A1 | PENTAPEPTIDE ASSOCIATED WITH INTEGRIN RECEPTOR ALPHA VBETA3 | CHINA PHARMACEUTICAL UNIVERSITY (CN) | 2018-05-24 | — | — | US | disclosed |
| WO-2016169239-A1 | 5 PEPTIDE RELATED WITH INTEGRIN RECEPTOR ΑVΒ3 | 中国药科大学 | 2016-10-27 | — | — | WO | disclosed |
| CN-104774247-A | Integrin receptor alpha-v-beta-3 related 5-peptide | UNIV CHINA PHARMA | 2015-07-15 | — | — | CN | disclosed |