Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Tryptophan. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSC | P53634 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | MPO | P05164 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | BLM | P54132 | 1/20 | 0.51 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.51 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.51 |
| ▸ | MMP1 | P03956 | 4/20 | 0.46 |
| ▸ | ECE1 | P42892 | 6/20 | 0.42 |
| ▸ | APAF1 | O14727 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.42 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | MMP8 | P22894 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tryptophan SCHEMBL6244660 | 1.00 | CTSC (0.52) | CTSCMEN1KMT2AKDM4EMAPT | |
| Tryptophan SCHEMBL6246810 | 0.98 | CTSC (0.54) | CTSCMEN1KMT2AKDM4EMAPT | |
| Tryptophan SCHEMBL18171551 | 0.91 | CTSC (0.54) | CTSCMEN1KMT2AKDM4EMAPT | |
| Dl-Tryptophan SCHEMBL28221613 | 0.91 | CTSC (0.54) | CTSCMEN1KMT2AKDM4EMAPT | |
| Tryptophan SCHEMBL6839207 | 0.91 | MEN1 (0.44) | CTSCMEN1KMT2AKDM4EMAPT | |
| Dl-Tryptophan SCHEMBL28338052 | 0.89 | KDM4E (0.55) | MEN1KMT2AKDM4EMAPTLMNA | |
| Dl-Tryptophan SCHEMBL10527592 | 0.87 | KMT2A (0.53) | MEN1KMT2AKDM4EMAPTLMNA | |
| Dl-Tryptophan SCHEMBL27657501 | 0.87 | KDM4E (0.56) | MEN1KMT2AKDM4EMAPTLMNA | |
| Tryptophan SCHEMBL23698367 | 0.87 | CTSC (0.51) | CTSCMEN1KMT2AKDM4EMAPT | |
| Dl-Tryptophan SCHEMBL28512622 | 0.86 | KDM4E (0.68) | CTSCMEN1KMT2AKDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1558137-A2 | FUNCTIONAL MRI AGENTS FOR CANCER IMAGING | Research Corporation Technologies (US) | 2005-08-03 | — | — | EP | disclosed |
| US-20040146463-A1 | Functional MRI agents for cancer imaging | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2004-07-29 | — | — | US | disclosed |
| WO-2004037210-A2 | FUNCTIONAL MRI AGENTS FOR CANCER IMAGING | RESEARCH CORPORATION TECHNOLOGIES (US) | 2004-05-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040146463-A1 | Functional MRI agents for cancer imaging | TSG101, SMARCE1, SMARCA1 | CTSC 4052/4885MEN1 61/4885KMT2A 847/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.