Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | APEX1 | P27695 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28817913 | 0.83 | NPSR1 (0.56) | ALDH1A1HPGDKDM4EMAPTNPSR1 | |
| SCHEMBL6987458 | 0.82 | NR3C2 (0.48) | ALDH1A1NPSR1L3MBTL1NR3C2KMT2A | |
| SCHEMBL22731945 | 0.81 | HSD11B1 (0.53) | GAAHSD17B10ALDH1A1HPGDALOX15 | |
| SCHEMBL29574308 | 0.81 | HSD11B1 (0.53) | GAAHSD17B10ALDH1A1HPGDALOX15 | |
| SCHEMBL9681622 | 0.79 | ALDH1A1 (0.57) | GAAHSD17B10ALDH1A1HPGDKDM4E | |
| SCHEMBL462999 | 0.78 | MAPK14 (0.50) | GAAHSD17B10ALDH1A1HPGDALOX15 | |
| SCHEMBL6313155 | 0.78 | ALDH1A1 (0.53) | GAAHSD17B10ALDH1A1HPGDALOX15 | |
| SCHEMBL6174962 | 0.78 | MAPT (0.57) | GAAKDM4EMAPTLMNAGLA | |
| SCHEMBL25314471 | 0.76 | SLC5A1 (0.42) | GAAALDH1A1HPGDKDM4EMAPT | |
| SCHEMBL17844090 | 0.76 | ALDH1A1 (0.67) | GAAHSD17B10ALDH1A1HPGDALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3286178-A1 | AMINO-SUBSTITUTED HETEROCYCLIC DERIVATIVES AS SODIUM CHANNEL INHIBITORS | Almirall S.A. (ES) | 2018-02-28 | — | — | EP | disclosed |
| WO-2016170009-A1 | AMINO-SUBSTITUTED HETEROCYCLIC DERIVATIVES AS SODIUM CHANNEL INHIBITORS | ALMIRALL, S.A. (ES) | 2016-10-27 | — | — | WO | disclosed |