Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 5/20 | 0.79 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.64 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.64 |
| ▸ | BTK | Q06187 | 1/20 | 0.51 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.49 |
| ▸ | UGCG | Q16739 | 1/20 | 0.48 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1691413 | 0.89 | MAPK14 (0.74) | MAPK14SCN5ASCN9ABTKUGCG | |
| SCHEMBL30120752 | 0.89 | MAPK14 (0.74) | MAPK14SCN5ASCN9ABTKUGCG | |
| SCHEMBL18172027 | 0.85 | MAPK14 (0.59) | MAPK14SCN5ASCN9ABTKPTPN1 | |
| SCHEMBL6320610 | 0.84 | MAPK14 (0.61) | MAPK14SCN5ASCN9AUGCGALDH1A1 | |
| SCHEMBL17844090 | 0.83 | ALDH1A1 (0.67) | MAPK14SCN5ASCN9AALDH1A1HPGD | |
| SCHEMBL3493407 | 0.82 | MAPK14 (0.58) | MAPK14SCN5ASCN9AUGCGALDH1A1 | |
| SCHEMBL6405465 | 0.80 | MAPT (0.63) | MAPK14SCN5ASCN9AALDH1A1HPGD | |
| SCHEMBL30785633 | 0.80 | MAPT (0.63) | MAPK14SCN5ASCN9AALDH1A1HPGD | |
| SCHEMBL1457162 | 0.80 | MAPK14 (0.62) | MAPK14SCN5ASCN9ABTKUGCG | |
| SCHEMBL18172112 | 0.79 | SCN9A (1.00) | MAPK14SCN5ASCN9ATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3286178-A1 | AMINO-SUBSTITUTED HETEROCYCLIC DERIVATIVES AS SODIUM CHANNEL INHIBITORS | Almirall S.A. (ES) | 2018-02-28 | — | — | EP | disclosed |
| WO-2016170009-A1 | AMINO-SUBSTITUTED HETEROCYCLIC DERIVATIVES AS SODIUM CHANNEL INHIBITORS | ALMIRALL, S.A. (ES) | 2016-10-27 | — | — | WO | disclosed |