Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 4/20 | 0.40 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.39 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31165861 | 0.81 | AR (0.48) | DEGS1SMN1; SMN2KDM4EMEN1KMT2A | |
| SCHEMBL9191562 | 0.81 | TSHR (0.61) | TSHRSMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL9191455 | 0.81 | TDP1 (0.63) | TDP1TSHRSMN1; SMN2ALDH1A1HTT | |
| SCHEMBL31357331 | 0.81 | TSHR (0.61) | TSHRSMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL26653746 | 0.79 | HSD17B10 (0.54) | TDP1TSHRDEGS1SMN1; SMN2ALDH1A1 | |
| SCHEMBL16230884 | 0.79 | TSHR (0.46) | TDP1TSHRDEGS1SMN1; SMN2ALDH1A1 | |
| SCHEMBL9188600 | 0.78 | RAB9A (0.53) | DEGS1SMN1; SMN2KDM4ERAB9A | |
| SCHEMBL9188906 | 0.77 | CYP1A2 (0.61) | SMN1; SMN2KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL3408832 | 0.76 | TSHR (0.68) | TSHRDEGS1SMN1; SMN2RAB9A | |
| SCHEMBL9206404 | 0.75 | CA12 (0.63) | CA12CA1CA2CA9ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3286178-A1 | AMINO-SUBSTITUTED HETEROCYCLIC DERIVATIVES AS SODIUM CHANNEL INHIBITORS | Almirall S.A. (ES) | 2018-02-28 | — | — | EP | disclosed |
| WO-2016170009-A1 | AMINO-SUBSTITUTED HETEROCYCLIC DERIVATIVES AS SODIUM CHANNEL INHIBITORS | ALMIRALL, S.A. (ES) | 2016-10-27 | — | — | WO | disclosed |