Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.61 |
| ▸ | MEN1 | O00255 | 3/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 2/20 | 0.59 |
| ▸ | RXFP1 | Q9HBX9 | 7/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.50 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.49 |
| ▸ | HTR2C | P28335 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1816200 | 0.87 | POLB (0.58) | POLBMEN1KMT2ACYP1A2MAPT | |
| SCHEMBL30136216 | 0.85 | MAPT (0.62) | POLBMEN1KMT2ACYP1A2MAPT | |
| SCHEMBL7607788 | 0.85 | MAPT (0.62) | POLBMEN1KMT2ACYP1A2MAPT | |
| SCHEMBL7363345 | 0.83 | SIRT2 (0.50) | POLBMEN1KMT2ACYP1A2MAPT | |
| SCHEMBL2258748 | 0.82 | EPHX2 (0.67) | EPHX2 | |
| SCHEMBL13588433 | 0.81 | SMN1; SMN2 (0.59) | POLBMEN1KMT2ARXFP1ALDH1A1 | |
| SCHEMBL5182843 | 0.80 | POLB (0.74) | POLBMEN1KMT2ACYP1A2MAPT | |
| SCHEMBL9965475 | 0.79 | F10 (0.53) | POLBMEN1KMT2ARXFP1SIRT2 | |
| Trifluoroacetic Acid SCHEMBL3474669 | 0.78 | EPHX2 (0.62) | EPHX2 | |
| Trifluoroacetic Acid SCHEMBL7363342 | 0.77 | SIRT2 (0.65) | RXFP1ALDH1A1SIRT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7951805-B2 | Heterocyclic derivatives and their use as mediators of stearoyl-CoA desaturase | XENON PHARMACEUTICALS INC. (CA) | 2011-05-31 | — | — | US | disclosed |