Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 8/20 | 0.48 |
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | KLK7 | P49862 | 1/20 | 0.45 |
| ▸ | CETP | P11597 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HTR6 | P50406 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1817247 | 0.83 | POLB (0.61) | SIRT2RXFP1MAPTPOLBALDH1A1 | |
| SCHEMBL13588433 | 0.81 | SMN1; SMN2 (0.59) | SIRT2RXFP1HDAC3HDAC1HDAC2 | |
| Trifluoroacetic Acid SCHEMBL7363342 | 0.79 | SIRT2 (0.65) | SIRT2RXFP1TP53ALDH1A1KDM4E | |
| SCHEMBL11747871 | 0.78 | SIRT2 (0.64) | SIRT2RXFP1MAPTCETPHDAC3 | |
| SCHEMBL31367875 | 0.77 | SIRT2 (0.59) | SIRT2RXFP1ALDH1A1KDM4EMEN1 | |
| SCHEMBL31098661 | 0.75 | HTR6 (0.60) | SIRT2ALDH1A1HTR6KDM4ESMN1; SMN2 | |
| SCHEMBL8132848 | 0.74 | SMN1; SMN2 (0.74) | JAK2ALDH1A1KDM4ESMN1; SMN2TSHR | |
| SCHEMBL29361009 | 0.74 | SMN1; SMN2 (0.74) | JAK2ALDH1A1KDM4ESMN1; SMN2TSHR | |
| SCHEMBL13981695 | 0.74 | QDPR (0.54) | — | |
| SCHEMBL641080 | 0.74 | GAA (0.62) | SIRT2SMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140903-A1 | AROMATIC AMIDES | ELI LILLY AND COMPANY (US) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000039118-A1 | AROMATIC AMIDES | ELI LILLY AND COMPANY (US) | 2000-07-06 | — | — | WO | disclosed |