Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | ITGB3 | P05106 | 3/20 | 0.35 |
| ▸ | ITGA2B | P08514 | 3/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | ACE | P12821 | 2/20 | 0.33 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21088636 | 0.82 | ALDH1A1 (0.32) | HDAC8HDAC1HDAC6 | |
| SCHEMBL2559463 | 0.82 | KDM4E (0.48) | — | |
| SCHEMBL27742591 | 0.79 | SMN1; SMN2 (0.31) | — | |
| SCHEMBL2555207 | 0.77 | HTT (0.37) | — | |
| SCHEMBL28949802 | 0.77 | SMN1; SMN2 (0.41) | — | |
| SCHEMBL2563080 | 0.76 | HDAC8 (0.34) | HDAC8HDAC1HDAC6 | |
| SCHEMBL15330391 | 0.76 | ALDH1A1 (0.56) | — | |
| SCHEMBL2555288 | 0.76 | OPRD1 (0.33) | — | |
| SCHEMBL29956260 | 0.76 | SIGMAR1 (0.51) | — | |
| SCHEMBL23291292 | 0.76 | HSD17B10 (0.56) | HSD17B10ITGB3ITGA2BALOX15ACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101180291-B | As 5-HT4Benzimidazole carboxamide compounds as receptor agonists | THERAVANCE INC | 2012-09-05 | — | — | CN | claimed |
| CN-101180291-A | As 5-HT4Benzimidazole carboxamide compounds as receptor agonists | THERAVANCE INC (US) | 2008-05-14 | — | — | CN | claimed |
| EP-3286172-A1 | LSD1 INHIBITORS AND USES THEREOF | Constellation Pharmaceuticals, Inc. (US) | 2018-02-28 | — | — | EP | disclosed |
| WO-2016172496-A1 | LSD1 INHIBITORS AND USES THEREOF | CONSTELLATION PHARMACEUTICALS, INC. (US) | 2016-10-27 | — | — | WO | disclosed |
| CN-101180291-B | As 5-HT4Benzimidazole carboxamide compounds as receptor agonists | THERAVANCE INC | 2012-09-05 | — | — | CN | disclosed |
| CN-101180291-A | As 5-HT4Benzimidazole carboxamide compounds as receptor agonists | THERAVANCE INC (US) | 2008-05-14 | — | — | CN | disclosed |