SCHEMBL18174575

SCHEMBL18174575

Cc1cc(-c2ccccn2)ccc1-c1c2ccccc2c(-c2ccc(-c3ccccn3)cc2C)c2cc(-c3ccccc3)ccc12

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DHODH Q02127 1/20 0.40
RET P07949 1/20 0.39
RIPK1 Q13546 1/20 0.39
RIPK3 Q9Y572 1/20 0.39
PDK2 Q15119 1/20 0.38
PRMT5 O14744 2/20 0.38
WDR77 Q9BQA1 1/20 0.38
KDM4E B2RXH2 3/20 0.37
NPC1 O15118 1/20 0.37
GRM5 P41594 1/20 0.36
PKMYT1 Q99640 1/20 0.36
ALDH1A1 P00352 2/20 0.36
LMNA P02545 2/20 0.36
MAPT P10636 2/20 0.36
HPGD P15428 2/20 0.36
SMN1; SMN2 Q16637 2/20 0.36
TSHR P16473 2/20 0.36
HSD17B10 Q99714 2/20 0.36
TP53 P04637 1/20 0.36
PKM P14618 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18174612 0.97 DHODH (0.39) DHODHRETRIPK1RIPK3PDK2
SCHEMBL18174558 0.90 KDM4E (0.44) DHODHRETRIPK1RIPK3PDK2
SCHEMBL15160908 0.90 KDM4E (0.37) DHODHRETRIPK1RIPK3KDM4E
SCHEMBL18174576 0.90 KDM4E (0.37) DHODHRETRIPK1RIPK3KDM4E
SCHEMBL18174588 0.90 RET (0.41) DHODHRETRIPK1RIPK3PDK2
SCHEMBL18174602 0.89 SMN1; SMN2 (0.42) DHODHRETRIPK1RIPK3PDK2
SCHEMBL15160992 0.87 GRM5 (0.37) DHODHPDK2KDM4ENPC1GRM5
SCHEMBL18174676 0.85 HTR2C (0.42) DHODHRETRIPK1RIPK3PDK2
SCHEMBL18174650 0.84 WNT3A (0.45) DHODHRETRIPK1RIPK3PDK2
SCHEMBL18174574 0.83 PIK3CA (0.48) DHODHKDM4EALDH1A1LMNAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9478750-B2 Anthracene derivative and organic electroluminescent element using the same JNC CORPORATION (JP) 2016-10-25 US disclosed
US-9478750-B2 Anthracene derivative and organic electroluminescent element using the same JNC CORPORATION (JP) 2016-10-25 US disclosed