SCHEMBL18174579

SCHEMBL18174579

Cc1c(-c2ccncc2)cccc1-c1c2ccccc2c(-c2cccc(-c3ccncc3)c2C)c2cc(-c3ccccc3)ccc12

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PIK3CA P42336 2/20 0.49
IMPDH2 P12268 1/20 0.48
MKNK1 Q9BUB5 1/20 0.43
NOTUM Q6P988 1/20 0.42
KDM4E B2RXH2 2/20 0.41
ALDH1A1 P00352 2/20 0.41
MAPT P10636 2/20 0.41
MEN1 O00255 1/20 0.41
LMNA P02545 1/20 0.41
RECQL P46063 1/20 0.41
KMT2A Q03164 1/20 0.41
NPSR1 Q6W5P4 1/20 0.41
CYP17A1 P05093 1/20 0.40
CYP1A2 P05177 1/20 0.40
PDCD1 Q15116 1/20 0.40
CD274 Q9NZQ7 1/20 0.40
PRKCI P41743 1/20 0.39
KIF11 P52732 1/20 0.39
CHEK1 O14757 2/20 0.38
EPHX1 P07099 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15977853 0.87 PIK3CA (0.55) PIK3CAIMPDH2MKNK1NOTUMKDM4E
SCHEMBL18174563 0.87 IMPDH2 (0.45) IMPDH2NOTUMKDM4EALDH1A1MAPT
SCHEMBL18174584 0.86 CYP11B1 (0.44) MKNK1KDM4ELMNACYP17A1CYP1A2
SCHEMBL18174664 0.83 PIK3CA (0.46) PIK3CAIMPDH2MKNK1NOTUMKDM4E
SCHEMBL18174574 0.83 PIK3CA (0.48) PIK3CAIMPDH2MKNK1NOTUMKDM4E
SCHEMBL10030037 0.83 PIK3CA (0.51) PIK3CAIMPDH2MKNK1NOTUMKDM4E
SCHEMBL10030025 0.83 PIK3CA (0.51) PIK3CAIMPDH2MKNK1NOTUMKDM4E
SCHEMBL10030038 0.81 PIK3CA (0.49) PIK3CAIMPDH2MKNK1NOTUMKDM4E
SCHEMBL18174604 0.81 PIK3CA (0.47) PIK3CAIMPDH2MKNK1NOTUMKDM4E
SCHEMBL18174587 0.81 PDCD1 (0.39) PIK3CAKDM4EALDH1A1MAPTLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9478750-B2 Anthracene derivative and organic electroluminescent element using the same JNC CORPORATION (JP) 2016-10-25 US disclosed
US-9478750-B2 Anthracene derivative and organic electroluminescent element using the same JNC CORPORATION (JP) 2016-10-25 US disclosed