Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 2/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.36 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15384288 | 0.87 | TRPA1 (0.37) | TRPA1KDM4E | |
| SCHEMBL18175106 | 0.68 | NPC1 (0.50) | NPC1KDM4EPOLB | |
| SCHEMBL12878629 | 0.59 | NPC1 (0.50) | PDE4APDE4BPDE4CPDE4DADORA2B | |
| SCHEMBL17192909 | 0.58 | POLB (0.36) | SMN1; SMN2POLB | |
| SCHEMBL10881570 | 0.57 | KDM4E (0.65) | NPC1KDM4ESMN1; SMN2POLB | |
| SCHEMBL11531219 | 0.57 | ADORA2B (0.78) | PDE4APDE4BPDE4CPDE4DADORA2B | |
| SCHEMBL16374759 | 0.57 | MEN1 (0.42) | PDE4APDE4BPDE4CPDE4DADORA2B | |
| SCHEMBL15493510 | 0.56 | CSNK2A1 (0.73) | PDE4APDE4BPDE4CPDE4DADORA2B | |
| SCHEMBL11983579 | 0.56 | NPC1 (0.59) | PDE4APDE4BPDE4CPDE4DADORA2B | |
| SCHEMBL22521924 | 0.56 | ALDH1A1 (0.46) | ADORA2BKDM4ESMN1; SMN2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2170309-B1 | 2,6-DIOXO,-2,3-DIHYDRO-1H-PURINE COMPOUNDS USEFUL FOR TREATING DISORDERS RELATED TO THE ACTIVITY OF THE TRPA1 CHANNEL | HYDRA BIOSCIENCES INC (US) | 2016-10-26 | — | — | EP | disclosed |