Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.68 |
| ▸ | MMP13 | P45452 | 3/20 | 0.68 |
| ▸ | HTT | P42858 | 1/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.68 |
| ▸ | HPGD | P15428 | 3/20 | 0.62 |
| ▸ | POLB | P06746 | 1/20 | 0.62 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.60 |
| ▸ | LMNA | P02545 | 2/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.60 |
| ▸ | USP2 | O75604 | 1/20 | 0.60 |
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | APEX1 | P27695 | 1/20 | 0.59 |
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.58 |
| ▸ | GFER | P55789 | 1/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3815151 | 0.87 | ALDH1A1 (0.72) | ALDH1A1MMP13HTTSMN1; SMN2HPGD | |
| SCHEMBL660541 | 0.85 | MMP13 (0.70) | ALDH1A1MMP13HTTSMN1; SMN2HPGD | |
| SCHEMBL2931410 | 0.85 | MMP13 (0.70) | ALDH1A1MMP13HTTSMN1; SMN2HPGD | |
| SCHEMBL8245692 | 0.84 | ALDH1A1 (0.68) | ALDH1A1MMP13HTTSMN1; SMN2HPGD | |
| Hydrochloric Acid SCHEMBL29194804 | 0.84 | MMP13 (0.68) | ALDH1A1MMP13HTTSMN1; SMN2HPGD | |
| SCHEMBL30104666 | 0.84 | ALDH1A1 (0.68) | ALDH1A1MMP13HTTSMN1; SMN2HPGD | |
| SCHEMBL13853495 | 0.83 | ALDH1A1 (0.67) | ALDH1A1MMP13HTTSMN1; SMN2HPGD | |
| SCHEMBL934348 | 0.83 | ALDH1A1 (0.76) | ALDH1A1MMP13HTTSMN1; SMN2HPGD | |
| SCHEMBL23771131 | 0.81 | ALDH1A1 (0.65) | ALDH1A1MMP13HTTSMN1; SMN2HPGD | |
| SCHEMBL15471187 | 0.81 | MMP13 (0.65) | ALDH1A1MMP13HTTSMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2616469-B1 | 9H-PURINE COMPOUNDS AS PI3K-DELTA INHIBITORS AND METHODS FOR THEIR MANUFACTURE | EXELIXIS INC (US) | 2016-10-26 | — | — | EP | disclosed |