Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | GRM5 | P41594 | 1/20 | 0.34 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.34 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.34 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.34 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.34 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.34 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | POLB | P06746 | 3/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4393 | 0.90 | NR4A2 (0.40) | TRPV1PTPN1TP53MAPTTHRB | |
| SCHEMBL3926 | 0.84 | ALDH1A1 (0.42) | TRPV1TP53MAPTCACNA1FABCB1 | |
| SCHEMBL4401 | 0.77 | LPAR1 (0.39) | TRPV1ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL4402 | 0.77 | L3MBTL1 (0.41) | GAANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL2219 | 0.75 | TRPV1 (0.39) | TRPV1KMT2APTPN1TP53MAPT | |
| SCHEMBL1784 | 0.72 | ALDH1A1 (0.40) | TRPV1KMT2APTPN1TP53MAPT | |
| SCHEMBL799464 | 0.70 | HRH3 (0.49) | ALDH1A1 | |
| SCHEMBL1563 | 0.70 | PTPN1 (0.47) | TRPV1KMT2APTPN1TP53MAPT | |
| SCHEMBL27842850 | 0.70 | TP53 (0.40) | TRPV1KMT2APTPN1TP53MAPT | |
| SCHEMBL7475 | 0.69 | PTPN1 (0.40) | TRPV1KMT2APTPN1TP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2483251-B1 | POLYCYCLIC COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | AMIRA PHARMACEUTICALS INC (US) | 2016-10-26 | — | — | EP | disclosed |