Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | ACKR3 | P25106 | 9/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.34 |
| ▸ | HTR5A | P47898 | 1/20 | 0.34 |
| ▸ | GPR88 | Q9GZN0 | 1/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | PPARD | Q03181 | 1/20 | 0.33 |
| ▸ | PPARA | Q07869 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4131 | 0.86 | LPAR1 (0.46) | L3MBTL1RAB9ATSHRGAAACKR3 | |
| SCHEMBL4132 | 0.86 | LPAR1 (0.46) | L3MBTL1RAB9ATSHRGAAACKR3 | |
| SCHEMBL4401 | 0.80 | LPAR1 (0.39) | L3MBTL1RAB9ALMNASMN1; SMN2LPAR1 | |
| SCHEMBL4393 | 0.79 | NR4A2 (0.40) | LPAR1 | |
| SCHEMBL18176069 | 0.77 | TRPV1 (0.40) | RAB9ASMN1; SMN2GAANPC1 | |
| SCHEMBL5839 | 0.76 | LPAR1 (0.48) | L3MBTL1RAB9ALMNASMN1; SMN2TSHR | |
| SCHEMBL3926 | 0.74 | ALDH1A1 (0.42) | LMNASMN1; SMN2TSHR | |
| SCHEMBL1604 | 0.71 | L3MBTL1 (0.37) | L3MBTL1RAB9ALMNASMN1; SMN2TSHR | |
| SCHEMBL6770 | 0.71 | RAB9A (0.42) | L3MBTL1RAB9ALMNASMN1; SMN2TSHR | |
| SCHEMBL1743 | 0.71 | L3MBTL1 (0.41) | L3MBTL1RAB9ALMNASMN1; SMN2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2483251-A2 | POLYCYCLIC COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | Amira Pharmaceuticals, Inc. (US) | 2012-08-08 | — | — | EP | disclosed |
| WO-2011041462-A2 | POLYCYCLIC COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | AMIRA PHARMACEUTICALS, INC. (US) | 2011-04-07 | — | — | WO | disclosed |