SCHEMBL181777

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

	Compound	similarity	top predicted	shared targets
	SCHEMBL181778	1.00	SCN9A (0.36)	SCN9AEPHX2CYP2C9CYP3A4CAPN1
	SCHEMBL181932	0.90	CYP51A1 (0.38)	SCN9ACYP2C9CYP3A4MEN1ALDH1A1
	SCHEMBL181931	0.90	CYP51A1 (0.38)	SCN9ACYP2C9CYP3A4MEN1ALDH1A1
	SCHEMBL181597	0.90	KMT2A (0.38)	CYP2C9CYP3A4MEN1ALDH1A1KMT2A
	SCHEMBL181596	0.90	KMT2A (0.38)	CYP2C9CYP3A4MEN1ALDH1A1KMT2A
	SCHEMBL181770	0.90	MC4R (0.39)	MC4RMEN1ALDH1A1KMT2ATACR1
	SCHEMBL181769	0.90	MC4R (0.39)	MC4RMEN1ALDH1A1KMT2ATACR1
	SCHEMBL185369	0.89	KMT2A (0.39)	CYP3A4MC4RMEN1ALDH1A1KMT2A
	SCHEMBL185368	0.89	KMT2A (0.39)	CYP3A4MC4RMEN1ALDH1A1KMT2A
	SCHEMBL181887	0.88	MC4R (0.43)	SCN9AEPHX2CYP2C9MC4RMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.