⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1834660 | 0.81 | ALDH1A1 (0.35) | — | |
| SCHEMBL14351571 | 0.79 | — | — | |
| SCHEMBL1817793 | 0.77 | — | — | |
| SCHEMBL14351305 | 0.75 | — | — | |
| SCHEMBL14351468 | 0.74 | ALDH1A1 (0.31) | — | |
| SCHEMBL14351469 | 0.74 | ALDH1A1 (0.31) | — | |
| SCHEMBL1820774 | 0.72 | HTR4 (0.36) | — | |
| SCHEMBL12234427 | 0.71 | LMNA (0.32) | — | |
| SCHEMBL3431890 | 0.66 | AOC3 (0.41) | — | |
| SCHEMBL8848028 | 0.66 | HCAR2 (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130005730-A1 | NOVEL 1,3-OXAZOLIDINE COMPOUNDS AND THEIR USE AS RENIN INHIBITORS | MEDIVIR AB (SE) | 2013-01-03 | — | — | US | disclosed |
| EP-2499120-A1 | NOVEL 1,3-OXAZOLIDINE COMPOUNDS AND THEIR USE AS RENIN INHIBITORS | Novadex Pharmaceuticals AB (SE) | 2012-09-19 | — | — | EP | disclosed |
| WO-2011056126-A1 | NOVEL 1,3-OXAZOLIDINE COMPOUNDS AND THEIR USE AS RENIN INHIBITORS | NOVADEX PHARMACEUTICALS AB (SE) | 2011-05-12 | — | — | WO | disclosed |