Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAX8 | Q06710 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | CNR1 | P21554 | 1/20 | 0.44 |
| ▸ | L3MBTL3 | Q96JM7 | 3/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | TP53BP1 | Q12888 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10574538 | 0.81 | ALDH1A1 (0.58) | PAX8ALDH1A1KDM4ECNR1L3MBTL1 | |
| SCHEMBL18184487 | 0.79 | PAX8 (0.55) | PAX8ALDH1A1KDM4ECNR1MAPK1 | |
| SCHEMBL4498993 | 0.79 | ALDH1A1 (0.53) | PAX8ALDH1A1KDM4ECNR1L3MBTL1 | |
| SCHEMBL18184488 | 0.76 | PAX8 (0.50) | PAX8ALDH1A1KDM4ECNR1MAPK1 | |
| SCHEMBL6037163 | 0.72 | KDM4E (0.70) | ALDH1A1KDM4ECNR1MAPK1EPHX2 | |
| SCHEMBL10572949 | 0.72 | ALDH1A1 (0.56) | ALDH1A1KDM4ECNR1L3MBTL1EPHX2 | |
| SCHEMBL30793971 | 0.72 | KDM4E (0.54) | PAX8ALDH1A1KDM4ECNR1L3MBTL1 | |
| SCHEMBL13826420 | 0.72 | EPHX2 (0.54) | ALDH1A1KDM4ECNR1HRH3EPHX2 | |
| SCHEMBL2603243 | 0.71 | KDM4E (0.50) | ALDH1A1KDM4ECNR1L3MBTL1EPHX2 | |
| SCHEMBL16002869 | 0.71 | EPHX2 (0.56) | ALDH1A1KDM4ECNR1L3MBTL1EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016172631-A2 | SUBSTRATE SELECTIVE INHIBITORS OF INSULIN-DEGRADING ENZYME (IDE) AND USES THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2016-10-27 | — | — | WO | disclosed |