Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | CNR1 | P21554 | 1/20 | 0.50 |
| ▸ | PAX8 | Q06710 | 2/20 | 0.45 |
| ▸ | KDR | P35968 | 1/20 | 0.45 |
| ▸ | CXCR4 | P61073 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | FNTA | P49354 | 2/20 | 0.43 |
| ▸ | FNTB | P49356 | 2/20 | 0.43 |
| ▸ | ECE2 | P0DPD6 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | SCN7A | Q01118 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1243996 | 0.94 | KDM4E (0.59) | KDM4EALDH1A1CNR1KDRL3MBTL1 | |
| SCHEMBL10574538 | 0.86 | ALDH1A1 (0.58) | KDM4EALDH1A1CNR1PAX8KDR | |
| SCHEMBL8672473 | 0.80 | L3MBTL1 (0.56) | KDM4EALDH1A1L3MBTL1TSHRSMN1; SMN2 | |
| SCHEMBL13621171 | 0.77 | KDM4E (0.59) | KDM4EALDH1A1CNR1L3MBTL1TSHR | |
| SCHEMBL17937010 | 0.77 | ALDH1A1 (0.59) | KDM4EALDH1A1CNR1L3MBTL1TSHR | |
| SCHEMBL5428790 | 0.77 | ALDH1A1 (0.47) | KDM4EALDH1A1CNR1TSHRSMN1; SMN2 | |
| SCHEMBL18114721 | 0.76 | TPSAB1 (0.45) | KDM4EALDH1A1L3MBTL1SMN1; SMN2ECE2 | |
| SCHEMBL10574244 | 0.75 | HSD17B10 (0.62) | KDM4EALDH1A1CNR1SMN1; SMN2HPGD | |
| SCHEMBL13118001 | 0.75 | KDM4E (0.64) | KDM4EALDH1A1CNR1TSHRSMN1; SMN2 | |
| SCHEMBL18123313 | 0.74 | NAMPT (0.44) | KDM4EALDH1A1FNTAFNTBECE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250368649-A1 | TETRAHYDROPYRIDOPYRIMIDINE PAN-KRAS INHIBITORS | MIRATI THERAPEUTICS INC (US) | 2025-12-04 | — | — | US | disclosed |
| EP-4540254-A1 | TETRAHYDROPYRIDOPYRIMIDINE PAN-KRAS INHIBITORS | Mirati Therapeutics, Inc. (US) | 2025-04-23 | — | — | EP | disclosed |
| WO-2023244604-A1 | TETRAHYDROPYRIDOPYRIMIDINE PAN-KRAS INHIBITORS | Mirati Therapeutics, Inc. (US) | 2023-12-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250368649-A1 | TETRAHYDROPYRIDOPYRIMIDINE PAN-KRAS INHIBITORS | KRAS, NRAS, HRAS | KDM4E 2625/4885ALDH1A1 3283/4885CNR1 1759/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.