Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 7/20 | 0.51 |
| ▸ | MAPT | P10636 | 5/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 7/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | HPGD | P15428 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | AHR | P35869 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 3/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4402960 | 0.80 | ALOX15 (0.63) | RAB9AMAPTSMN1; SMN2GAANPC1 | |
| SCHEMBL4404496 | 0.80 | ALDH1A1 (0.54) | RAB9ASMN1; SMN2NPC1ALDH1A1MEN1 | |
| SCHEMBL3595259 | 0.79 | MAPT (0.54) | RAB9AMAPTSMN1; SMN2GAANPC1 | |
| SCHEMBL1644064 | 0.79 | NPC1 (0.54) | RAB9AMAPTSMN1; SMN2GAANPC1 | |
| SCHEMBL30134133 | 0.79 | NPC1 (0.54) | RAB9AMAPTSMN1; SMN2GAANPC1 | |
| SCHEMBL27293915 | 0.78 | MAPT (0.56) | RAB9AMAPTSMN1; SMN2GAANPC1 | |
| SCHEMBL13614180 | 0.77 | MEN1 (0.66) | RAB9AMAPTSMN1; SMN2GAANPC1 | |
| SCHEMBL10746855 | 0.77 | MAPT (0.62) | RAB9AMAPTSMN1; SMN2GAANPC1 | |
| SCHEMBL15069589 | 0.76 | NPC1 (0.50) | RAB9AMAPTSMN1; SMN2GAANPC1 | |
| SCHEMBL12201007 | 0.76 | ADORA3 (0.50) | RAB9AMAPTSMN1; SMN2GAANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110300752-A | Monocycle OGA inhibitor compound | 詹森药业有限公司 | 2019-10-01 | — | — | CN | disclosed |
| CN-110267961-A | OGA inhibitor compound | 詹森药业有限公司 | 2019-09-20 | — | — | CN | disclosed |
| WO-2016172631-A2 | SUBSTRATE SELECTIVE INHIBITORS OF INSULIN-DEGRADING ENZYME (IDE) AND USES THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2016-10-27 | — | — | WO | disclosed |