Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK2 | Q15119 | 2/20 | 0.47 |
| ▸ | BRD4 | O60885 | 1/20 | 0.47 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.42 |
| ▸ | CYSLTR2 | Q9NS75 | 2/20 | 0.41 |
| ▸ | CYSLTR1 | Q9Y271 | 2/20 | 0.41 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | ALDH2 | P05091 | 2/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | FAAH | O00519 | 2/20 | 0.39 |
| ▸ | LTA4H | P09960 | 4/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.38 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18189670 | 1.00 | PDK2 (0.47) | PDK2BRD4PDE3BPDE3ACYSLTR2 | |
| SCHEMBL18189646 | 0.96 | PDK2 (0.47) | PDK2BRD4PDE3BPDE3ACYSLTR2 | |
| SCHEMBL18189647 | 0.96 | PDK2 (0.47) | PDK2BRD4PDE3BPDE3ACYSLTR2 | |
| SCHEMBL18197348 | 0.92 | BRD4 (0.47) | PDK2BRD4PDE3BPDE3ACYSLTR2 | |
| SCHEMBL18189561 | 0.89 | HPGD (0.47) | PDE3BPDE3AP2RY12PTPN1ALDH2 | |
| SCHEMBL18189559 | 0.89 | HPGD (0.47) | PDE3BPDE3AP2RY12PTPN1ALDH2 | |
| SCHEMBL18189622 | 0.89 | PDK2 (0.43) | PDK2PDE3BPDE3ACYSLTR2CYSLTR1 | |
| SCHEMBL18189625 | 0.89 | PDK2 (0.43) | PDK2PDE3BPDE3ACYSLTR2CYSLTR1 | |
| SCHEMBL20175901 | 0.89 | MEN1 (0.43) | PDK2LTA4H | |
| SCHEMBL20164301 | 0.89 | HPGD (0.39) | PDK2BRD4PDE3BPDE3AP2RY12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10570104-B2 | Metabolically programmed metal chelators and uses thereof | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (US) | 2020-02-25 | — | — | US | disclosed |
| US-20180140581-A1 | METABOLICALLY PROGRAMMED METAL CHELATORS AND USES THEREOF | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (US) | 2018-05-24 | — | — | US | disclosed |
| EP-3288557-A1 | METABOLICALLY PROGRAMMED METAL CHELATORS AND USES THEREOF | University of Florida Research Foundation, Inc. (US) | 2018-03-07 | — | — | EP | disclosed |
| WO-2016176343-A1 | METABOLICALLY PROGRAMMED METAL CHELATORS AND USES THEREOF | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (US) | 2016-11-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10570104-B2 | Metabolically programmed metal chelators and uses thereof | FECH, SLC19A1, SLC40A1 | PDK2 322/4885BRD4 4761/4885PDE3B 4363/4885 |
| US-20180140581-A1 | METABOLICALLY PROGRAMMED METAL CHELATORS AND USES THEREOF | FECH, SLC19A1, SLC40A1 | PDK2 322/4885BRD4 4761/4885PDE3B 4363/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.