Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.35 |
| ▸ | LCK | P06239 | 1/20 | 0.34 |
| ▸ | KHK | P50053 | 2/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | CDK1 | P06493 | 1/20 | 0.33 |
| ▸ | STK10 | O94804 | 1/20 | 0.33 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | GBA1 | P04062 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19929884 | 0.84 | PTK2 (0.37) | PTK2KHKKDRGBA1 | |
| SCHEMBL19929867 | 0.82 | PTK2 (0.36) | KMT2APTK2KHKKDRP2RX7 | |
| SCHEMBL18194350 | 0.81 | PDE2A (0.41) | P2RX7NPC1RAB9ACDK1SLK | |
| SCHEMBL29051296 | 0.80 | KDR (0.50) | KMT2AKDRNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL18194324 | 0.77 | MAPT (0.45) | KMT2ASMN1; SMN2ALOX15MAPTLMNA | |
| SCHEMBL19921129 | 0.74 | PDE5A (0.46) | — | |
| SCHEMBL3950993 | 0.74 | KMT2A (0.39) | KMT2APTK2KHKP2RX7NPC1 | |
| SCHEMBL19921135 | 0.73 | CCNK (0.50) | PTK2 | |
| SCHEMBL18194338 | 0.73 | KHK (0.36) | KMT2AKHKP2RX7NPC1RAB9A | |
| SCHEMBL19867253 | 0.73 | HTT (0.45) | KMT2ANPC1RAB9ASMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3290420-B1 | PYRIMIDINE PYRROLE COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION, AND USES THEREOF | UNIV XIAMEN (CN) | 2020-12-09 | — | — | EP | disclosed |
| EP-3290420-A1 | PYRIMIDINE PYRROLE COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION, AND USES THEREOF | Xiamen University (CN) | 2018-03-07 | — | — | EP | disclosed |
| WO-2016173477-A1 | PYRIMIDINE PYRROLE COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION, AND USES THEREOF | 厦门大学 | 2016-11-03 | — | — | WO | disclosed |