Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK2 | Q05397 | 1/20 | 0.36 |
| ▸ | GBA1 | P04062 | 1/20 | 0.33 |
| ▸ | KHK | P50053 | 2/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | IGF1R | P08069 | 1/20 | 0.31 |
| ▸ | EIF4E | P06730 | 2/20 | 0.31 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.31 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.31 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.31 |
| ▸ | CDK2 | P24941 | 1/20 | 0.31 |
| ▸ | PLK1 | P53350 | 1/20 | 0.31 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.31 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.31 |
| ▸ | PLK2 | Q9NYY3 | 1/20 | 0.31 |
| ▸ | TERT | O14746 | 1/20 | 0.31 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.30 |
| ▸ | PIP4K2C | Q8TBX8 | 1/20 | 0.30 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19929884 | 0.89 | PTK2 (0.37) | PTK2GBA1KHKKDRIGF1R | |
| SCHEMBL18194347 | 0.82 | KMT2A (0.39) | PTK2GBA1KHKKDRP2RX7 | |
| SCHEMBL19921129 | 0.79 | PDE5A (0.46) | ALDH1A1 | |
| SCHEMBL19921135 | 0.78 | CCNK (0.50) | PTK2CCNA2CDK2 | |
| SCHEMBL19929862 | 0.78 | PIP4K2C (0.33) | KDREIF4EMKNK1MKNK2PIP4K2C | |
| SCHEMBL22730041 | 0.75 | IRAK4 (0.45) | PTK2CCNA2CDK2PLK1 | |
| SCHEMBL19921100 | 0.73 | ALK (0.52) | PTK2IGF1R | |
| SCHEMBL19929891 | 0.73 | EGFR (0.41) | IGF1RCCNA2CDK2KDM4E | |
| SCHEMBL22754173 | 0.71 | IRAK4 (0.35) | KDR | |
| SCHEMBL19929901 | 0.71 | BCHE (0.41) | CDK2PLK1PIP4K2CP2RX7KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3290420-A1 | PYRIMIDINE PYRROLE COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION, AND USES THEREOF | Xiamen University (CN) | 2018-03-07 | — | — | EP | disclosed |