Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 1/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.68 |
| ▸ | TSHR | P16473 | 2/20 | 0.68 |
| ▸ | LMNA | P02545 | 1/20 | 0.68 |
| ▸ | MAPT | P10636 | 1/20 | 0.68 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.68 |
| ▸ | POLB | P06746 | 2/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | RYR2 | Q92736 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | PHGDH | O43175 | 1/20 | 0.40 |
| ▸ | MGLL | Q99685 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Diethylcarbamazine SCHEMBL67289 | 1.00 | HTR1A (1.00) | HTR1AKDM4EALDH1A1TSHRLMNA | |
| Diethylcarbamazine SCHEMBL10412471 | 0.98 | HTR1A (0.96) | HTR1AKDM4EALDH1A1TSHRLMNA | |
| Diethylcarbamazine SCHEMBL2719699 | 0.96 | HTR1A (0.92) | HTR1AKDM4EALDH1A1TSHRLMNA | |
| SCHEMBL11096507 | 0.94 | HTR1A (0.89) | HTR1AKDM4EALDH1A1TSHRLMNA | |
| Diethylcarbamazine SCHEMBL27894397 | 0.91 | HTR1A (0.82) | HTR1AKDM4EALDH1A1TSHRLMNA | |
| Diethylcarbamazine SCHEMBL28938729 | 0.89 | HTR1A (0.79) | HTR1AKDM4EALDH1A1TSHRLMNA | |
| Diethylcarbamazine SCHEMBL2319899 | 0.89 | HTR1A (0.79) | HTR1AKDM4EALDH1A1TSHRLMNA | |
| SCHEMBL11506548 | 0.85 | HTR1A (0.74) | HTR1AKDM4EALDH1A1TSHRLMNA | |
| SCHEMBL21140593 | 0.82 | HTR1A (0.69) | HTR1AKDM4EALDH1A1TSHRLMNA | |
| Diethylcarbamazine SCHEMBL37736 | 0.82 | KDM4E (1.00) | HTR1AKDM4EALDH1A1TSHRLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3137065-A2 | COMPOSITIONS, METHODS AND USES FOR THE TREATMENT OF DIABETIC NEUROPATHIES | Pharnext (FR) | 2017-03-08 | — | — | EP | disclosed |
| EP-3038614-A1 | COMPOSITION COMPRISING TORASEMIDE AND BACLOFEN FOR TREATING NEUROLOGICAL DISORDERS | Pharnext (FR) | 2016-07-06 | — | — | EP | disclosed |
| WO-2015165948-A2 | COMPOSITIONS, METHODS AND USES FOR THE TREATMENT OF DIABETIC NEUROPATHIES | PHARNEXT (FR) | 2015-11-05 | — | — | WO | disclosed |
| WO-2015028659-A1 | COMPOSITION COMPRISING TORASEMIDE AND BACLOFEN FOR TREATING NEUROLOGICAL DISORDERS | PHARNEXT (FR) | 2015-03-05 | — | — | WO | disclosed |
| EP-2560631-A2 | BACLOFEN AND ACAMPROSATE BASED THERAPY OF NEUROGICAL DISORDERS | Pharnext (FR) | 2013-02-27 | — | — | EP | disclosed |
| EP-2496226-A1 | NEW THERAPEUTIC APPROACHES FOR TREATING ALZHEIMER DISEASE | Pharnext (FR) | 2012-09-12 | — | — | EP | disclosed |
| WO-2012117076-A2 | BACLOFEN AND ACAMPROSATE BASED THERAPY OF NEUROGICAL DISORDERS | PHARNEXT (FR) | 2012-09-07 | — | — | WO | disclosed |
| WO-2012117073-A2 | NEW COMPOSITIONS FOR TREATING NEUROLOGICAL DISORDERS | PHARNEXT (FR) | 2012-09-07 | — | — | WO | disclosed |
| WO-2011054759-A1 | NEW THERAPEUTIC APPROACHES FOR TREATING ALZHEIMER DISEASE | PHARNEXT (FR) | 2011-05-12 | — | — | WO | disclosed |
| US-4442086-A | Diethylcarbamazine resinate and styrylpyridinium resinate-diethylcarbamazine resinate edible anthelmintic tablets for companion animals | AMERICAN CYANAMID COMPANY (US) | 1984-04-10 | — | — | US | disclosed |
| US-4151188-A | COMBATTING FILARIASIS IN DOGS | FRIEDHEIM ERNST A H (CH) | 1979-04-24 | — | — | US | disclosed |