Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Diethylcarbamazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 1/20 | 0.82 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.59 |
| ▸ | TSHR | P16473 | 2/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.40 |
| ▸ | RYR2 | Q92736 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Diethylcarbamazine SCHEMBL1819685 | 0.91 | HTR1A (1.00) | HTR1AKDM4EALDH1A1TSHRLMNA | |
| Diethylcarbamazine SCHEMBL67289 | 0.91 | HTR1A (1.00) | HTR1AKDM4EALDH1A1TSHRLMNA | |
| Diethylcarbamazine SCHEMBL10412471 | 0.89 | HTR1A (0.96) | HTR1AKDM4EALDH1A1TSHRLMNA | |
| Diethylcarbamazine SCHEMBL2719699 | 0.87 | HTR1A (0.92) | HTR1AKDM4EALDH1A1TSHRLMNA | |
| SCHEMBL11096507 | 0.85 | HTR1A (0.89) | HTR1AKDM4EALDH1A1TSHRLMNA | |
| Diethylcarbamazine SCHEMBL28938729 | 0.81 | HTR1A (0.79) | HTR1AKDM4EALDH1A1TSHRLMNA | |
| Diethylcarbamazine SCHEMBL2319899 | 0.81 | HTR1A (0.79) | HTR1AKDM4EALDH1A1TSHRLMNA | |
| SCHEMBL11506548 | 0.77 | HTR1A (0.74) | HTR1AKDM4EALDH1A1TSHRLMNA | |
| SCHEMBL21140593 | 0.75 | HTR1A (0.69) | HTR1AKDM4EALDH1A1TSHRLMNA | |
| Stearic Acid SCHEMBL10523832 | 0.74 | HTR1A (0.68) | HTR1AKDM4EALDH1A1TSHRLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102741252-A | Spiroindoline compounds useful as insect repellents | INTERVET INT BV | 2012-10-17 | — | — | CN | disclosed |