Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 10/20 | 0.41 |
| ▸ | KDM1B | Q8NB78 | 2/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 2/20 | 0.34 |
| ▸ | HTR2C | P28335 | 2/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.33 |
| ▸ | NOS3 | P29474 | 1/20 | 0.33 |
| ▸ | NOS1 | P29475 | 1/20 | 0.33 |
| ▸ | NOS2 | P35228 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | MAOB | P27338 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15428151 | 0.75 | KDM1A (0.30) | KDM1AKDM1BKCNH2 | |
| SCHEMBL31590344 | 0.75 | KDM1A (0.30) | KDM1AKDM1BKCNH2 | |
| SCHEMBL4406720 | 0.73 | CHRNB2 (0.47) | KDM1AKDM1BCA1CA2HTR2A | |
| SCHEMBL853286 | 0.69 | CHRNB4 (0.40) | KDM1AKDM1BHTR2ASLC6A2 | |
| SCHEMBL11526900 | 0.68 | CHRNA1 (0.51) | NOS3NOS1NOS2SLC6A2SLC6A4 | |
| SCHEMBL11527764 | 0.68 | CHRNB2 (0.53) | KDM1ACA1CA2HTR2AHTR2C | |
| SCHEMBL1819320 | 0.68 | KDM1A (0.41) | KDM1AKDM1BNOS3NOS1NOS2 | |
| SCHEMBL20627668 | 0.68 | KDM1A (0.41) | KDM1AKDM1BNOS3NOS1NOS2 | |
| SCHEMBL25934423 | 0.67 | KDM1A (0.37) | KDM1AKDM1BKCNH2 | |
| SCHEMBL5380020 | 0.67 | KDM4E (0.35) | KDM1ACA1CA2HTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021078217-A1 | TETRACENE DERIVATIVE, PREPARATION METHOD THEREFOR, AND USE THEREOF | 中国科学院化学研究所 | 2021-04-29 | — | — | WO | disclosed |
| EP-2560959-B1 | PROCESS FOR THE PREPARATION OF PYRAZOLE CARBOXYLIC ACID AMIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2014-08-20 | — | — | EP | disclosed |
| EP-2316809-B1 | Process for the preparation of benzonorbornane derivatives | SYNGENTA PARTICIPATIONS AG (CH) | 2014-06-18 | — | — | EP | disclosed |
| EP-2560960-B1 | PROCESS FOR THE PREPARATION OF PYRAZOLE CARBOXYLIC ACID AMIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2014-02-26 | — | — | EP | disclosed |
| US-8524915-B2 | Process for the preparation of pyrazole carboxylic acid amides | SYNGENTA CROP PROTECTION LLC (US) | 2013-09-03 | — | — | US | disclosed |
| US-8519152-B2 | Process for the preparation of pyrazole carboxylic acid amides | SYNGENTA CROP PROTECTION LLC (US) | 2013-08-27 | — | — | US | disclosed |
| EP-2560960-A1 | PROCESS FOR THE PREPARATION OF PYRAZOLE CARBOXYLIC ACID AMIDES | Syngenta Participations AG (CH) | 2013-02-27 | — | — | EP | disclosed |
| US-20130041160-A1 | PROCESS FOR THE PREPARATION OF PYRAZOLE CARBOXYLIC ACID AMIDES | SYNGENTA CROP PROTECTION LLC (US) | 2013-02-14 | — | — | US | disclosed |
| US-20130035496-A1 | PROCESS FOR THE PREPARATION OF PYRAZOLE CARBOXYLIC ACID AMIDES | SYNGENTA CROP PROTECTION LLC (US) | 2013-02-07 | — | — | US | disclosed |
| EP-1963251-B1 | PROCESS FOR THE PREPARATION OF AMINES | SYNGENTA PARTICIPATIONS AG (CH) | 2012-08-15 | — | — | EP | disclosed |
| WO-2011131544-A1 | PROCESS FOR THE PREPARATION OF PYRAZOLE CARBOXYLIC ACID AMIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2011-10-27 | — | — | WO | disclosed |
| EP-2316814-A1 | Process for preparation of halogen substituted benzonorbornenes derivatives | Syngenta Participations AG (CH) | 2011-05-04 | — | — | EP | disclosed |
| EP-2316813-A1 | Process for the preparation of amines | Syngenta Participations AG (CH) | 2011-05-04 | — | — | EP | disclosed |
| EP-2316809-A1 | Process for the preparation of benzonorbornane derivatives | Syngenta Participations AG (CH) | 2011-05-04 | — | — | EP | disclosed |
| EP-2316815-A1 | Process for preparation of halogen substituted arynes | Syngenta Participations AG (CH) | 2011-05-04 | — | — | EP | disclosed |
| US-7781615-B2 | Process for the preparation of amines | SYNGENTA CROP PROTECTION, INC. (US) | 2010-08-24 | — | — | US | disclosed |
| US-20090221856-A1 | PROCESS FOR THE PREPARATION OF AMINES | SYNGENTA CROP PROTECTION, INC. (US) | 2009-09-03 | — | — | US | disclosed |
| EP-1963251-A2 | PROCESS FOR THE PREPARATION OF AMINES | Syngeta Participations AG (CH) | 2008-09-03 | — | — | EP | disclosed |
| WO-2007068417-A2 | PROCESS FOR THE PREPARATION OF AMINES | SYNGENTA PARTICIPATIONS AG (CH) | 2007-06-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130035496-A1 | PROCESS FOR THE PREPARATION OF PYRAZOLE CARBOXYLIC ACID AMIDES | F5, F12, F9 | KDM1A 3085/4885KDM1B 3521/4885CA1 54/4885 |
| US-20090221856-A1 | PROCESS FOR THE PREPARATION OF AMINES | HRH3, PAH, C1R | KDM1A 272/4885KDM1B 161/4885CA1 2150/4885 |
| US-20130041160-A1 | PROCESS FOR THE PREPARATION OF PYRAZOLE CARBOXYLIC ACID AMIDES | CBR3, F12, CBR1 | KDM1A 1903/4885KDM1B 1519/4885CA1 150/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.