Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 2/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.30 |
| ▸ | KDM1B | Q8NB78 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31590344 | 1.00 | KDM1A (0.30) | KDM1AKCNH2KDM1B | |
| SCHEMBL16905394 | 0.79 | PRKDC (0.40) | — | |
| SCHEMBL14316854 | 0.72 | — | — | |
| SCHEMBL19825894 | 0.72 | — | — | |
| SCHEMBL915720 | 0.69 | — | — | |
| SCHEMBL15416743 | 0.67 | CHRNB2 (0.34) | KDM1AKCNH2KDM1B | |
| SCHEMBL4406720 | 0.65 | CHRNB2 (0.47) | KDM1AKDM1B | |
| SCHEMBL16904169 | 0.65 | — | — | |
| SCHEMBL853286 | 0.65 | CHRNB4 (0.40) | KDM1AKDM1B | |
| SCHEMBL14316867 | 0.64 | CHRNB2 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3016959-B1 | POLYCYCLIC COMPOUNDS | MERCK PATENT GMBH (DE) | 2017-12-27 | — | — | EP | disclosed |
| US-9837622-B2 | Metal complexes | MERCK PATENT GMBH (DE) | 2017-12-05 | — | — | US | disclosed |
| US-9837622-B2 | Metal complexes | MERCK PATENT GMBH (DE) | 2017-12-05 | — | — | US | disclosed |
| US-20160204358-A1 | POLYCYCLIC COMPOUNDS | MERCK PATENT GMBH (DE) | 2016-07-14 | — | — | US | disclosed |
| US-20160204358-A1 | POLYCYCLIC COMPOUNDS | MERCK PATENT GMBH (DE) | 2016-07-14 | — | — | US | disclosed |
| US-20150263297-A1 | Metal Complexes | MERCK PATENT GMBH (DE) | 2015-09-17 | — | — | US | disclosed |
| US-20150263297-A1 | Metal Complexes | MERCK PATENT GMBH (DE) | 2015-09-17 | — | — | US | disclosed |
| WO-2015000546-A1 | POLYCYCLIC COMPOUNDS | MERCK PATENT GMBH (DE) | 2015-01-08 | — | — | WO | disclosed |
| WO-2014008982-A1 | METAL COMPLEXES | MERCK PATENT GMBH (DE) | 2014-01-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150263297-A1 | Metal Complexes | SOD1, AP1M1, AP3M1 | KDM1A 4098/4885KCNH2 187/4885KDM1B 3685/4885 |
| US-20160204358-A1 | POLYCYCLIC COMPOUNDS | VDAC2, VDAC3, KCNC1 | KDM1A 3299/4885KCNH2 15/4885KDM1B 2788/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.