Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 7/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14048229 | 0.81 | POLB (0.47) | METKDM4EALDH1A1MKNK1POLB | |
| SCHEMBL18197862 | 0.73 | MET (0.60) | MET | |
| SCHEMBL14306269 | 0.69 | MKNK1 (0.38) | MKNK1PDE4ADYRK1A | |
| SCHEMBL11785295 | 0.69 | MKNK1 (0.38) | MKNK1PDE4ADYRK1A | |
| SCHEMBL2763216 | 0.69 | MKNK1 (0.38) | METMKNK1PDE4ADYRK1A | |
| SCHEMBL2764570 | 0.69 | KDM4E (0.50) | KDM4EALDH1A1MKNK1POLBPDE4A | |
| SCHEMBL9935156 | 0.69 | MKNK1 (0.38) | MKNK1PDE4ADYRK1A | |
| SCHEMBL16417549 | 0.69 | SMN1; SMN2 (0.41) | KDM4EALDH1A1MKNK1PDE4ACYP1A2 | |
| SCHEMBL749848 | 0.69 | ALDH1A1 (0.51) | KDM4EALDH1A1CYP1A2 | |
| SCHEMBL2265391 | 0.69 | MKNK1 (0.35) | MKNK1CYP1A2DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1966214-B9 | TRIAZOLOPYRIDAZINES AS TYROSINE KINASE MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2017-09-13 | — | — | EP | disclosed |
| EP-1966214-B1 | TRIAZOLOPYRIDAZINES AS TYROSINE KINASE MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2016-11-02 | — | — | EP | disclosed |