Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 1/20 | 0.50 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.46 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
| ▸ | PPARA | Q07869 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | RGS12 | O14924 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | APEX1 | P27695 | 1/20 | 0.43 |
| ▸ | THPO | P40225 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4397024 | 0.91 | AKR1B1 (0.56) | AKR1B1LTB4RLTB4R2KDM4EALDH1A1 | |
| SCHEMBL4397023 | 0.91 | AKR1B1 (0.56) | AKR1B1LTB4RLTB4R2KDM4EALDH1A1 | |
| SCHEMBL10374325 | 0.86 | LTB4R (0.59) | AKR1B1LTB4RLTB4R2KDM4EALDH1A1 | |
| SCHEMBL8324775 | 0.86 | LTB4R (0.59) | AKR1B1LTB4RLTB4R2KDM4EALDH1A1 | |
| SCHEMBL4683483 | 0.83 | PPARG (0.47) | AKR1B1LTB4RLTB4R2KDM4EALDH1A1 | |
| SCHEMBL27840537 | 0.83 | MMP1 (0.55) | AKR1B1KDM4EALDH1A1PKMMMP1 | |
| SCHEMBL4683487 | 0.83 | PPARG (0.47) | AKR1B1LTB4RLTB4R2KDM4EALDH1A1 | |
| SCHEMBL2388359 | 0.81 | AKR1B1 (0.54) | AKR1B1KDM4EALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL4682641 | 0.81 | PPARG (0.46) | AKR1B1LTB4RLTB4R2KDM4EALDH1A1 | |
| SCHEMBL4682644 | 0.81 | PPARG (0.46) | AKR1B1LTB4RLTB4R2KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1966214-B1 | TRIAZOLOPYRIDAZINES AS TYROSINE KINASE MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2016-11-02 | — | — | EP | disclosed |