Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 3/20 | 0.41 |
| ▸ | CA1 | P00915 | 3/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | CA2 | P00918 | 3/20 | 0.36 |
| ▸ | MMP2 | P08253 | 3/20 | 0.36 |
| ▸ | MMP9 | P14780 | 3/20 | 0.36 |
| ▸ | MMP8 | P22894 | 2/20 | 0.36 |
| ▸ | MMP1 | P03956 | 2/20 | 0.36 |
| ▸ | MMP13 | P45452 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HPGDS | O60760 | 1/20 | 0.35 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.34 |
| ▸ | FEN1 | P39748 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | MMP3 | P08254 | 1/20 | 0.34 |
| ▸ | MMP7 | P09237 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18198028 | 1.00 | CNR2 (0.41) | CNR2CA1CA12CA9ALDH1A1 | |
| SCHEMBL18198038 | 1.00 | CNR2 (0.41) | CNR2CA1CA12CA9ALDH1A1 | |
| SCHEMBL18198127 | 0.86 | ALDH1A1 (0.42) | CNR2CA1ALDH1A1CA2MMP2 | |
| SCHEMBL18198003 | 0.86 | ALDH1A1 (0.42) | CNR2CA1ALDH1A1CA2MMP2 | |
| SCHEMBL18198009 | 0.86 | ALDH1A1 (0.42) | CNR2CA1ALDH1A1CA2MMP2 | |
| SCHEMBL5514483 | 0.82 | ALDH1A1 (0.52) | CA1ALDH1A1CA2MMP2MMP9 | |
| SCHEMBL16886883 | 0.82 | CA1 (0.39) | CNR2CA1CA12CA9ALDH1A1 | |
| SCHEMBL16886882 | 0.82 | CA1 (0.39) | CNR2CA1CA12CA9ALDH1A1 | |
| SCHEMBL3247810 | 0.82 | CA1 (0.39) | CNR2CA1CA12CA9ALDH1A1 | |
| SCHEMBL19901363 | 0.81 | ECE1 (0.41) | CNR2CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9902726-B2 | Pyridone-sulfone morphinan analogs as opioid receptor ligands | PURDUE PHARMA L.P. (US) | 2018-02-27 | — | — | US | disclosed |
| US-9902726-B2 | Pyridone-sulfone morphinan analogs as opioid receptor ligands | PURDUE PHARMA L.P. (US) | 2018-02-27 | — | — | US | disclosed |
| US-20160318932-A1 | PYRIDONE-SULFONE MORPHINAN ANALOGS AS OPIOID RECEPTOR LIGANDS | PURDUE PHARMA L.P. | 2016-11-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160318932-A1 | PYRIDONE-SULFONE MORPHINAN ANALOGS AS OPIOID RECEPTOR LIGANDS | OPRK1, OPRM1, OPRL1 | CNR2 25/4885CA1 4837/4885CA12 4863/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.