Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 2/20 | 0.43 |
| ▸ | MAOB | P27338 | 2/20 | 0.43 |
| ▸ | CA1 | P00915 | 2/20 | 0.42 |
| ▸ | CA2 | P00918 | 2/20 | 0.42 |
| ▸ | CA9 | Q16790 | 2/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA4 | P22748 | 1/20 | 0.39 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.39 |
| ▸ | CCR2 | P41597 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13745303 | 0.87 | MAOA (0.47) | MAOAMAOBCA1CA2CA9 | |
| SCHEMBL23779534 | 0.85 | MAOB (0.52) | MAOAMAOBCA1CA2CA9 | |
| SCHEMBL29634429 | 0.85 | MAOB (0.52) | MAOAMAOBCA1CA2CA9 | |
| SCHEMBL15464302 | 0.83 | MAOA (0.41) | MAOAMAOBCA1CA2CA9 | |
| SCHEMBL3001729 | 0.83 | MAOA (0.43) | MAOAMAOBCA1CA2CA9 | |
| SCHEMBL14426934 | 0.81 | ALDH1A1 (0.51) | LMNAALDH1A1CYP3A4TP53GLA | |
| SCHEMBL14792917 | 0.80 | MAOB (0.57) | MAOAMAOBCA1CA2CA9 | |
| SCHEMBL589307 | 0.80 | MAOB (0.50) | MAOAMAOBCA1CA2CA9 | |
| SCHEMBL30279898 | 0.80 | MAOB (0.50) | MAOAMAOBCA1CA2CA9 | |
| SCHEMBL14426942 | 0.79 | KMT2A (0.52) | LMNACYP3A4KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2909183-B1 | 4-(ORTHO)-FLUOROPHENYL-5-FLUOROPYRIMIDIN-2-YL AMINES CONTAINING A SULFONE GROUP | Bayer Pharma AG (DE) | 2016-08-24 | — | — | EP | disclosed |
| EP-2909183-B1 | 4-(ORTHO)-FLUOROPHENYL-5-FLUOROPYRIMIDIN-2-YL AMINES CONTAINING A SULFONE GROUP | Bayer Pharma AG (DE) | 2016-08-24 | — | — | EP | disclosed |
| US-20150259300-A1 | 4-(ORTHO)-FLUOROPHENYL-5-FLUOROPYRIMIDIN-2-YL AMINES CONTAINING A SULFONE GROUP | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2015-09-17 | — | — | US | disclosed |
| US-20150259300-A1 | 4-(ORTHO)-FLUOROPHENYL-5-FLUOROPYRIMIDIN-2-YL AMINES CONTAINING A SULFONE GROUP | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2015-09-17 | — | — | US | disclosed |
| US-20150259300-A1 | 4-(ORTHO)-FLUOROPHENYL-5-FLUOROPYRIMIDIN-2-YL AMINES CONTAINING A SULFONE GROUP | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2015-09-17 | — | — | US | disclosed |
| EP-2909183-A1 | 4-(ORTHO)-FLUOROPHENYL-5-FLUOROPYRIMIDIN-2-YL AMINES CONTAINING A SULFONE GROUP | Bayer Pharma Aktiengesellschaft (DE) | 2015-08-26 | — | — | EP | disclosed |
| WO-2014060376-A1 | 4-(ORTHO)-FLUOROPHENYL-5-FLUOROPYRIMIDIN-2-YL AMINES CONTAINING A SULFONE GROUP | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2014-04-24 | — | — | WO | disclosed |
| WO-2014060376-A1 | 4-(ORTHO)-FLUOROPHENYL-5-FLUOROPYRIMIDIN-2-YL AMINES CONTAINING A SULFONE GROUP | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2014-04-24 | — | — | WO | disclosed |
| US-8461134-B2 | Boron-containing small molecules | ANACOR PHARMACEUTICALS, INC. (US) | 2013-06-11 | — | — | US | disclosed |
| US-20110172187-A1 | BORON-CONTAINING SMALL MOLECULES | ANACOR PHARMACEUTICALS, INC. (US) | 2011-07-14 | — | — | US | disclosed |
| WO-2011060196-A1 | BORON-CONTAINING SMALL MOLECULES | ANACOR PHARMACEUTICALS, INC. (US) | 2011-05-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150259300-A1 | 4-(ORTHO)-FLUOROPHENYL-5-FLUOROPYRIMIDIN-2-YL AMINES CONTAINING A SULFONE GROUP | PAH, ABL1, OAT | MAOA 150/4885MAOB 37/4885CA1 4854/4885 |
| US-20110172187-A1 | BORON-CONTAINING SMALL MOLECULES | BCL6B, BCL6, BTD | MAOA 2465/4885MAOB 301/4885CA1 4452/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.